ArticleThe Journal of membrane biology2003
Human adipose cells have voltage-dependent potassium currents.
Article in The Journal of membrane biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Novel function of TREK-1 in regulating adipocyte differentiation and lipid accumulation.Cell death & disease · 2025Article
- Exploring the Potential of Carotenoids in Obesity Management: A Comprehensive Overview.Recent advances in food, nutrition & agriculture · 2025Review
- Physiological effects of microcurrent and its application for maximising acute responses and chronic adaptations to exercise.European journal of applied physiology · 2023Review
- Effects of Abdominal Microcurrent in the Consumption and Proportion of Energy Substrates during Aerobic Exercise: A Pilot Study.Healthcare (Basel, Switzerland) · 2022Article
- Role of TRPV4 Channel in Human White Adipocytes Metabolic Activity.Endocrinology and metabolism (Seoul, Korea) · 2021Article
- Caveolar targeting links Kv1.3 with the insulin-dependent adipocyte physiology.Cellular and molecular life sciences : CMLS · 2018Article
- Liquid Metal Enabled Electrobiology: A New Frontier to Tackle Disease Challenges.Micromachines · 2018Review
- Ion Channels in Obesity: Pathophysiology and Potential Therapeutic Targets.Frontiers in pharmacology · 2016Review
- Perivascular adipose tissue-derived adiponectin activates BK(Ca) channels to induce anticontractile responses.American journal of physiology. Heart and circulatory physiology · 2013Article
- An exploratory study of the association between KCNB1 rs1051295 and type 2 diabetes and its related traits in Chinese Han population.PloS one · 2013Article
- Functional differences in visceral and subcutaneous fat pads originate from differences in the adipose stem cell.PloS one · 2012Article
- Voltage-gated potassium channels as therapeutic targets.Nature reviews. Drug discovery · 2009Review
- K+ channel modulators for the treatment of neurological disorders and autoimmune diseases.Chemical reviews · 2008Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The whole-cell patch-clamp method was used to study the membrane electrical properties of human adipocyte cells obtained by differentiating from precursors of human abdominal and mammary tissues. All differentiated cells exhibited outward currents with sigmoidal activation kinetics. The outward currents showed activation thresholds between -20 to -30 mV and slow inactivation. The ionic channels underlying the macroscopic current were highly selective for K(+). Their selectivity was for typical K(+) channels with relative permeabilities of K(+)>NH4+>Cs(+)>Na(+). No evidence of any other type of voltage-gated channel was found. The potassium currents ( I(KV)) were blocked reversibly by tetraethylammonium and barium. The IC(50) value and Hill coefficient of tetraethylammonium inhibition of I(KV) were 0.56 m M and 1.17 respectively. These results demonstrate that human adipose cells have voltage-dependent potassium currents.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.