ReviewGene therapy2004
Aseptic loosening.
Review in Gene therapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 1 synthesis or guideline pooled it, 198 citations in OpenAlex.
- Highly cross-linked polyethylene in primary total knee arthroplasty is associated with a lower rate of revision for aseptic loosening: a meta-analysis of 962,467 cases.Archives of orthopaedic and trauma surgery · 2022Pooled it
- Long-Term Incidence of Peri-Implant Conditions: 25-Year Results of The Bernese Prospective Cohort Study.Clinical implant dentistry and related research · 2026Article
- Oxypaeoniflorin Ameliorates Titanium Particle-Stimulated Osteolysis by Targeting Nrf2 to Reprogram Mitochondrial Homeostasis in Osteoclasts.Journal of cellular and molecular medicine · 2026Article
- Impacts of mixing techniques and vacuum levels on the structural and mechanical properties of PMMA bone cement: A comparative study.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2026Article
- GREM1 acts in leptin receptor-expressing skeletal cells to mediate peri-implant fibrosis.Nature communications · 2026Article
- Nanoparticle-Loaded Injectable Hydrogel Alleviates Titanium Particle-Induced Osteolysis by Disrupting GATA6/DDX3X-Mediated Macrophage Inflammation.Biomaterials research · 2026Article
- Acute complications after reverse total shoulder arthroplasty for treatment of cuff arthropathy versus fracture.Clinics in shoulder and elbow · 2025Article
- Prevention and treatment of peri-implant fibrosis by functionally inhibiting skeletal cells expressing the leptin receptor.Nature biomedical engineering · 2024Article
- Orthopedic meta-implants.APL bioengineering · 2024Article
- The acute inflammatory response to copper(II)-doped biphasic calcium phosphates.Materials today. Bio · 2023Article
- Survivability of Titanium Implant Materials: In Vitro Simulated Inflammatory and Infectious Environment.Annals of biomedical engineering · 2023Article
- Matrix stiffness regulates osteoclast fate through integrin-dependent mechanotransduction.Bioactive materials · 2023Article
- Effect of cementing technique on aseptic stem loosening in cemented primary total hip arthroplasty: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2023Article
- 3D Biomimetic Calcified Cartilaginous Callus that Induces Type H Vessels Formation and Osteoclastogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Investigation of the Friction Properties of a New Artificial Imitation Cartilage Material: PHEMA/Glycerol Gel.Materials (Basel, Switzerland) · 2023Article
- Carboxymethyl chitosan regulates oxidative stress and decreases the expression levels of tumor necrosis factor α in macrophages induced by wear particles.Cytotechnology · 2023Article
- Mechanism of regulating macrophages/osteoclasts in attenuating wear particle-induced aseptic osteolysis.Frontiers in immunology · 2023Review
- Article
- Analysis of the Effect of Component Ratio Imbalances on Selected Mechanical Properties of Seasoned, Medium Viscosity Bone Cements.Materials (Basel, Switzerland) · 2022Article
- Surface coating of orthopedic implant to enhance the osseointegration and reduction of bacterial colonization: a review.Biomaterials research · 2022Review
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Although total joint replacement surgery is one of the most successful clinical procedures performed today, bone loss around knee and hip implants (osteolysis), resulting in aseptic loosening of the prosthesis, remains a major problem for many patients. Over the last decade much has been learned about this process, which is caused by wear debris particles that simulate a local inflammatory response and osteoclastic bone resorption. Aseptic loosening cannot be prevented or treated by existing nonsurgical methods. Gene transfer, however, offers novel possibilities. Here, we review the current state of the field and the experimental gene therapy approaches that have been investigated toward a solution to aseptic loosening of prosthetic implants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.