ArticleGene therapy2004
Cationic corticosteroid for nonviral gene delivery.
Article in Gene therapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 57 citations in OpenAlex.
- Linker-Free Hyaluronic Acid-Dexamethasone Conjugates: pH-Responsive Nanocarriers for Targeted Anti-Inflammatory Therapy.International journal of molecular sciences · 2025Article
- Dexamethasone Conjugates: Synthetic Approaches and Medical Prospects.Biomedicines · 2021Review
- Glucocorticoid Cell Priming Enhances Transfection Outcomes in Adult Human Mesenchymal Stem Cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2016Article
- Intracellular delivery of dendrimer triamcinolone acetonide conjugates into microglial and human retinal pigment epithelial cells.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2015Article
- Synthesis and structure-activity relationships of novel cationic lipids with anti-inflammatory and antimicrobial activities.Bioorganic & medicinal chemistry letters · 2015Article
- Ternary complexes with core-shell bilayer for double level targeted gene delivery: in vitro and in vivo evaluation.Pharmaceutical research · 2013Article
- Polymeric nucleic acid carriers: current issues and novel design approaches.Journal of controlled release : official journal of the Controlled Release Society · 2012Review
- Development of a successive targeting liposome with multi-ligand for efficient targeting gene delivery.The journal of gene medicine · 2011Article
- Novel cationic lipids with enhanced gene delivery and antimicrobial activity.Molecular pharmacology · 2010Article
- Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate.Antimicrobial agents and chemotherapy · 2010Article
- TLR9 and IRF3 cooperate to induce a systemic inflammatory response in mice injected with liposome:DNA.Molecular therapy : the journal of the American Society of Gene Therapy · 2010Article
- Cationic lipid formulations alter the in vivo tropism of AAV2/9 vector in lung.Molecular therapy : the journal of the American Society of Gene Therapy · 2009Article
- Pulmonary delivery of adenovirus vector formulated with dexamethasone-spermine facilitates homologous vector re-administration.Gene therapy · 2007Article
- Matrices and scaffolds for DNA delivery in tissue engineering.Advanced drug delivery reviews · 2007Review
- Design of modular non-viral gene therapy vectors.Biomaterials · 2006Review
- The effect of dexamethasone/cell-penetrating peptide nanoparticles on gene delivery for inner ear therapy.International journal of nanomedicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Delivery of plasmid DNA for gene therapy often provokes an inflammatory response that reduces transgene expression. Cationic lipids for lipofection lack pharmacological activity despite the hydrophobicity of many drug candidates that could be exploited. We report a one-step synthesis of a water-soluble, dexamethasone-spermine (DS) cationic lipid that has potent gene transfer capability in confluent endothelial cells when used with the neutral lipid, dioleoylphosphatidylethanolamine (DOPE). In contrast, unconjugated mixtures of dexamethasone, spermine, and/or DOPE have essentially no gene transfer activity. DS retains partial corticosteroid character as quantified by the rapid translocation of glucocorticoid receptor to the nucleus and by dose-dependent transactivation from a glucocorticoid response element. DS has anti-inflammatory activity in vivo in the mouse thioglycollate model of inflammation. In a mouse lung model, DS:DOPE resulted in significantly less interferon-gamma production at Day 1 and elevated transgene expression at Days 1 and 7 postintranasal instillation compared to DC-Chol:DOPE (sterol:DOPE:phosphate molar ratio of 1:1:1). Cationic pharmacophores such as DS represent a new approach to gene delivery and localized therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.