ArticleProceedings of the National Academy of Sciences of the United States of America2004
Complex and dynamic redistribution of NF-kappaB signaling intermediates in response to T cell receptor stimulation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 58 citations in OpenAlex.
- Bcl10 is associated with actin dynamics at the T cell immune synapse.Cellular immunology · 2020Article
- Periodic Membrane Potential and CaInternational journal of molecular sciences · 2020Article
- BCL10-CARD11 Fusion Mimics an Active CARD11 Seed That Triggers Constitutive BCL10 Oligomerization and Lymphocyte Activation.Frontiers in immunology · 2018Article
- CARMA3 Is a Critical Mediator of G Protein-Coupled Receptor and Receptor Tyrosine Kinase-Driven Solid Tumor Pathogenesis.Frontiers in immunology · 2018Review
- BCL10 - Bridging CARDs to Immune Activation.Frontiers in immunology · 2018Review
- TCR signaling to NF-κB and mTORC1: Expanding roles of the CARMA1 complex.Molecular immunology · 2015Review
- Probes to monitor activity of the paracaspase MALT1.Chemistry & biology · 2015Article
- T cell receptor signals to NF-κB are transmitted by a cytosolic p62-Bcl10-Malt1-IKK signalosome.Science signaling · 2014Article
- The CBM signalosome: potential therapeutic target for aggressive lymphoma?Cytokine & growth factor reviews · 2014Review
- A new look at T cell receptor signaling to nuclear factor-κB.Trends in immunology · 2013Review
- Kinase-independent feedback of the TAK1/TAB1 complex on BCL10 turnover and NF-κB activation.Molecular and cellular biology · 2013Article
- Regulation of NF-κB by the CARD proteins.Immunological reviews · 2012Review
- Involvement of distinct PKC gene products in T cell functions.Frontiers in immunology · 2012Article
- An active kinase domain is required for retention of PKCθ at the T cell immunological synapse.Molecular biology of the cell · 2011Article
- Regulation of NF-κB induction by TCR/CD28.Immunologic research · 2011Review
- NF-κB signaling pathways regulated by CARMA family of scaffold proteins.Cell research · 2011Review
- Cutting edge: TCR ligation triggers digital activation of NF-kappaB.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- PKC and the control of localized signal dynamics.Nature reviews. Molecular cell biology · 2010Review
- Malt1 and cIAP2-Malt1 as effectors of NF-kappaB activation: kissing cousins or distant relatives?Cellular signalling · 2010Review
- Expanding the multicolor capabilities of basic confocal microscopes by employing red and near-infrared quantum dot conjugates.BMC biotechnology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
The central zone of the supramolecular activation cluster (c-SMAC) is a zone of T cell receptor (TCR) enrichment that forms at a T cell/antigen-presenting cell (APC) junction in response to antigen stimulation. We demonstrate that there is a surprisingly complex relocalization process that brings PKC and Bcl10, two intermediates in TCR activation of NF-kappaB, to the cytoplasmic face of the c-SMAC. TCR activation causes enrichment of PKC at the c-SMAC, followed by Bcl10 relocalization to punctate cytoplasmic structures, often at sites distant from the c-SMAC. These Bcl10 structures then undergo further relocalization, becoming enriched at the c-SMAC. TCR activation of NF-kappaB therefore involves the dynamic relocalization of multiple signaling intermediates, with distinct phases proximal to and distant from the c-SMAC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.