ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Limited role of developmental programmed cell death pathways in Drosophila norpA retinal degeneration.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 28 citations in OpenAlex.
- Negative regulation of the novel norpA(P24) suppressor, diehard4, in the endo-lysosomal trafficking underlies photoreceptor cell degeneration.PLoS genetics · 2013Article
- Drosophila king tubby (ktub) mediates light-induced rhodopsin endocytosis and retinal degeneration.Journal of biomedical science · 2012Article
- Alternative pathway of cell death in Drosophila mediated by NF-κB transcription factor Relish.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Genetic control of necrosis - another type of programmed cell death.Current opinion in cell biology · 2010Review
- TOR-mediated autophagy regulates cell death in Drosophila neurodegenerative disease.The Journal of cell biology · 2009Article
- Accumulation of rhodopsin in late endosomes triggers photoreceptor cell degeneration.PLoS genetics · 2009Article
- Ionic dysregulatory phenotyping of pathologic retinal thinning with manganese-enhanced MRI.Investigative ophthalmology & visual science · 2008Article
- Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia.Genes & development · 2008Article
- Bim expression indicates the pathway to retinal cell death in development and degeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Phototransduction and retinal degeneration in Drosophila.Pflugers Archiv : European journal of physiology · 2007Review
- Regulation of phototransduction responsiveness and retinal degeneration by a phospholipase D-generated signaling lipid.The Journal of cell biology · 2005Article
- Review
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7 authors at 1 institution in 1 country.
Funding
Abstract
We examined the role of programmed cell death (PCD) pathways in retinal degeneration caused by a mutation in the norpA gene. norpA degeneration shows morphological hallmarks of programmed cell death, specifically cytoplasmic condensation and engulfment of the dying photoreceptor cells by neighboring retinal pigment cells. However, genetic mosaic analysis of adult photoreceptors lacking rpr, hid, and grim show that these PCD inducers are not required for norpA degeneration. We showed previously that ectopic expression of either rpr or hid triggers rapid PCD in adult photoreceptors, and this is completely suppressed by the coexpression of the baculoviral P35 caspase inhibitor. In contrast, expression of P35 does not suppress norpA retinal degeneration, although a small delay in the rate of degeneration is observed in low light-low temperature conditions. P35 does not alter the morphological characteristics of norpA cell death. Overexpression of the Drosophila inhibitor of apoptosis Diap1 or a dominant-negative form of the Dronc caspase, even when coexpressed with P35, does not dramatically alter the time course of norpA degeneration. These results establish that the pathways responsible for PCD in development do not play a major role in adult retinal degeneration caused by norpA.
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