ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Odorant receptor expression patterns are restored in lesion-recovered rat olfactory epithelium.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 145 citations in OpenAlex.
- A spatial code governs olfactory receptor choice and aligns sensory maps in the nose and brain.Cell · 2026Article
- New Neurons in the Postnatal Olfactory System: Functions in the Healthy and Regenerating Brain.Brain sciences · 2025Review
- The brain functional connectivity alterations in traumatic patients with olfactory disorder after low-level laser therapy demonstrated by fMRI.The neuroradiology journal · 2023Article
- Evaluation of children and adults with post-COVID-19 persistent smell, taste and trigeminal chemosensory disorders: A hospital based study.World journal of clinical pediatrics · 2023Article
- MRI tractography reveals the human olfactory nerve map connecting the olfactory epithelium and olfactory bulb.Communications biology · 2022Article
- Spatial organization of olfactory receptor gene choice in the complete V1R-related ORA family of zebrafish.Scientific reports · 2022Article
- Assessment of Smell and Taste Disturbances among COVID-19 Convalescent Patients: A Cross-Sectional Study in Armenia.Journal of clinical medicine · 2022Article
- Multi-Odor Discrimination by Rat Sniffing for Potential Monitoring of Lung Cancer and Diabetes.Sensors (Basel, Switzerland) · 2021Article
- A Group of Olfactory Receptor Alleles that Encode Full Length Proteins are Down-Regulated as Olfactory Sensory Neurons Mature.Scientific reports · 2020Article
- Tests of the chromatographic theory of olfaction with highly soluble odors: a combined electro-olfactogram and computational fluid dynamics study in the mouse.Biology open · 2019Article
- Spatial Determination of Neuronal Diversification in the Olfactory Epithelium.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Structure and zonal expression of olfactory receptors in the olfactory epithelium of the goat, Capra hircus.The Journal of veterinary medical science · 2018Article
- CanonicalThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Enhanced Homing Technique of Mesenchymal Stem Cells Using Iron Oxide Nanoparticles by Magnetic Attraction in Olfactory-Injured Mouse Models.International journal of molecular sciences · 2018Article
- Tests of the sorption and olfactory "fovea" hypotheses in the mouse.Journal of neurophysiology · 2017Article
- Olfactory sensory axons target specific protoglomeruli in the olfactory bulb of zebrafish.Neural development · 2017Article
- Stem and progenitor cells of the mammalian olfactory epithelium: Taking poietic license.The Journal of comparative neurology · 2017Review
- Olfactory receptor patterning in a higher primate.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- The regeneration of P2 olfactory sensory neurons is selectively impaired following methyl bromide lesion.Chemical senses · 2014Article
- The membrane proteome of sensory cilia to the depth of olfactory receptors.Molecular & cellular proteomics : MCP · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Lesions of the olfactory periphery provide a means for examining the reconstitution of a diverse and highly regulated population of sensory neurons and the growth, en masse, of nascent axons to the bulb. The olfactory epithelium and its projection onto the bulb are reconstituted after ablation by methyl bromide gas, and some measure of olfactory function is restored. The extent to which the system regenerates the full repertoire of odorant receptor-expressing neurons, particularly their spatially restricted distribution across the epithelial sheet, is unknown, however, and altered odorant receptor expression might contribute to the persistent distortion of odorant quality that is observed in the lesioned-recovered animals. To address the question of receptor expression in the recovered epithelium, we performed in situ hybridization with digoxigenin-labeled riboprobes for eight odorant receptors on the olfactory epithelium from unilaterally methyl bromide-lesioned and control rats. The data demonstrate that the distribution of sensory neuron types, as identified and defined by odorant receptor expression, is restored to normal or nearly so by 3 months after lesion. Likewise, the numbers of probe-labeled neurons in the lesioned-recovered epithelium are nearly equivalent to the unlesioned side at this time. Finally, our evidence suggests that odorant receptors are distributed in multiple overlapping bands in the normal, unlesioned, and lesioned-recovered epithelium rather than in the conventionally accepted three or four zones. Thus, the primary sensory elements required for functional recovery of the olfactory system after damage are restored, and altered function implies the persistence of a more central failure in regeneration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.