Trial reportThe Journal of physiology2004
Effect of gastric distension on cardiovascular parameters: gastrovascular reflex is attenuated in the elderly.
Trial report in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 53 citations in OpenAlex.
- The effect of water temperature on orthostatic tolerance: a randomised crossover trial.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Trial
- The effect of endogenously released glucose, insulin, glucagon-like peptide 1, ghrelin on cardiac output, heart rate, stroke volume, and blood pressure.Cardiovascular ultrasound · 2011Trial
- Effects of intraduodenal glucose concentration on blood pressure and heart rate in healthy older subjects.Digestive diseases and sciences · 2006Trial
- Subtle involvement of the parasympathetic nervous system in patients with irritable bowel syndrome.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2006Trial
- Article
- Regulation of Autonomic Motility in Human Gastric Muscle and the Gastroepiploic Artery by Stretch and pH.Journal of muscle research and cell motility · 2025Article
- Baroreflex function and postprandial hypotension in older adults.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Article
- Comparative effects of small intestinal glucose on blood pressure, heart rate, and noradrenaline responses in obese and healthy subjects.Physiological reports · 2018Article
- Comparative effects of glucose and water drinks on blood pressure and cardiac function in older subjects with and without postprandial hypotension.Physiological reports · 2017Article
- Nutrient stimulation of mesenteric blood flow - implications for older critically ill patients.World journal of critical care medicine · 2017Review
- Prevalence of and risk factors for postprandial hypotension in older Chinese men.Journal of geriatric cardiology : JGC · 2015Article
- The influence of oral water load on energy expenditure and sympatho-vagal balance in obese and normal weight women.Archives of medical science : AMS · 2012Article
- Postprandial hypotension in clinical geriatric patients and healthy elderly: prevalence related to patient selection and diagnostic criteria.Journal of aging research · 2010Article
- The effect of intraduodenal glucose on muscle sympathetic nerve activity in healthy young and older subjects.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2008Article
- Water intake accelerates post-exercise cardiac vagal reactivation in humans.European journal of applied physiology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stretching the stomach wall in young healthy subjects causes an increase in muscle sympathetic nerve activity and in blood pressure, the gastrovascular reflex. We compared healthy elderly subjects with healthy young subjects to find out whether the gastrovascular reflex attenuates in normal ageing and we studied whether there was a difference in autonomic function or gastric compliance that could explain this possible attenuation. Muscle sympathetic nerve activity, finger blood pressure and heart rate were continuously recorded during stepwise isobaric gastric distension using a barostat in eight healthy young (6 men and 2 women, 27 +/- 3.2 years, mean +/-s.e.m.) and eight healthy elderly subjects (7 men and 1 woman, 76 +/- 1.5 years). Changes in cardiac output and total peripheral arterial resistance were calculated from the blood pressure signal. The baseline mean arterial pressure and muscle sympathetic nerve activity were higher in the elderly group (both P < 0.05) and muscle sympathetic nerve activity increase during the cold pressor test was lower in the elderly group (P = 0.005). During stepwise gastric distension, the elderly subjects showed an attenuated increase in muscle sympathetic nerve activity compared to the young subjects (P < 0.01). The older group tended to show a higher increase in mean arterial pressure (P = 0.08), heart rate (P = 0.06) and total peripheral arterial resistance (P = 0.09) The cardiac output rose slightly in both groups without significant difference between groups. The fundic compliance did not differ between groups. We conclude that stepwise gastric distension caused an increase in muscle sympathetic nerve activity in both groups, but the increase in the elderly was attenuated.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.