ArticleThe Journal of physiology2004
Depletion of substance P and glutamate by capsaicin blocks respiratory rhythm in neonatal rat in vitro.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Glutamate tone in preBötzinger complex rhythmogenesis: ambient extracellular glutamate as a candidate excitability bias.Pflugers Archiv : European journal of physiology · 2026Review
- Predominant NR1-positive puncta with limited PSD95 colocalization and close GluA2-EAAT2 apposition in the preBötzinger complex.Histochemistry and cell biology · 2026Article
- The retrotrapezoid nucleus and the neuromodulation of breathing.Journal of neurophysiology · 2021Review
- Respiratory frequency plasticity during development.Respiratory physiology & neurobiology · 2019Review
- The contribution of endogenous glutamatergic input in the ventral respiratory column to respiratory rhythm.Respiratory physiology & neurobiology · 2019Article
- TRPV1 Inhibits the Ventilatory Response to Hypoxia in Adult Rats, but Not the CO₂-Drive to Breathe.Pharmaceuticals (Basel, Switzerland) · 2019Article
- Effects of a TRPV1 agonist capsaicin on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rats.Pflugers Archiv : European journal of physiology · 2017Article
- Article
- Tonic neuromodulation of the inspiratory rhythm generator.Frontiers in physiology · 2012Article
- Chapter 3--networks within networks: the neuronal control of breathing.Progress in brain research · 2011Review
- State-dependent interactions between excitatory neuromodulators in the neuronal control of breathing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Raphé neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Developmentally regulated and evolutionarily conserved expression of SLITRK1 in brain circuits implicated in Tourette syndrome.The Journal of comparative neurology · 2009Article
- Contributions of 5-HT neurons to respiratory control: neuromodulatory and trophic effects.Respiratory physiology & neurobiology · 2008Review
- Generation of eupnea and sighs by a spatiochemically organized inspiratory network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- High sensitivity to neuromodulator-activated signaling pathways at physiological [K+] of confocally imaged respiratory center neurons in on-line-calibrated newborn rat brainstem slices.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Neurokinin-1 receptor activation in Botzinger complex evokes bradypnoea.The Journal of physiology · 2006Article
- Looking for inspiration: new perspectives on respiratory rhythm.Nature reviews. Neuroscience · 2006Review
- Synergistic interactions between airway afferent nerve subtypes regulating the cough reflex in guinea-pigs.The Journal of physiology · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The specific role of the neuromodulator substance P (SP) and its target, the neurokinin 1 receptor (NK1R), in the generation and regulation of respiratory activity is not known. The preBötzinger complex (preBötC), an essential site for respiratory rhythm generation, contains glutamatergic NK1R-expressing neurones that are strongly modulated by exogenously applied SP or acute pharmacological blockade of NK1Rs. We investigated the effects of capsaicin, which depletes neuropeptides (including SP) and glutamate from presynaptic terminals, on respiratory motor output in medullary slice preparations of neonatal rat that generate respiratory-related activity. Bath application of capsaicin slowed respiratory motor output in a dose- and time-dependent manner. Respiratory rhythm could be restored by bath application of SP or glutamate transporter blockers. Capsaicin also evoked dose-dependent glutamate release and depleted SP in fibres within the preBötC. Our results suggest that depletion of SP (or other peptides) and/or glutamate by capsaicin causes a cessation of respiratory rhythm in neonatal rat slices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.