ArticleThe Journal of physiology2004
Transient receptor potential-like channels mediate metabotropic glutamate receptor EPSCs in rat dopamine neurones.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Glutamatergic Input From Arcuate Nucleus Kiss1 Neurons to Preoptic Kiss1 Neurons Is Required for LH Surge in Female Mice.Endocrinology · 2025Article
- Article
- Canonical transient receptor potential channels and hypothalamic control of homeostatic functions.Journal of neuroendocrinology · 2024Review
- Estradiol elicits distinct firing patterns in arcuate nucleus kisspeptin neurons of females through altering ion channel conductances.bioRxiv : the preprint server for biology · 2024Article
- Transient CaFrontiers in molecular biosciences · 2022Article
- Deletion ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- TRPC1 mediates slow excitatory synaptic transmission in hippocampal oriens/alveus interneurons.Molecular brain · 2020Article
- Regenerative Adaptation to Electrochemical Perturbation in Planaria: A Molecular Analysis of Physiological Plasticity.iScience · 2019Article
- Phosphoinositol metabolism affects AMP kinase-dependent K-ATP currents in rat substantia nigra dopamine neurons.Brain research · 2019Article
- TRPCing around the hypothalamus.Frontiers in neuroendocrinology · 2018Review
- GluD1, linked to schizophrenia, controls the burst firing of dopamine neurons.Molecular psychiatry · 2018Article
- Cholinergic receptor activation supports persistent firing in layer III neurons in the medial entorhinal cortex.Behavioural brain research · 2013Article
- The cellular building blocks of breathing.Comprehensive Physiology · 2012Review
- Transient receptor potential canonical channels regulate the induction of cerebellar long-term depression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Low-frequency summation of synaptically activated transient receptor potential channel-mediated depolarizations.The European journal of neuroscience · 2011Article
- The role of spiking and bursting pacemakers in the neuronal control of breathing.Journal of biological physics · 2011Article
- Calcium-activated non-selective cation currents are involved in generation of tonic and bursting activity in dopamine neurons of the substantia nigra pars compacta.The Journal of physiology · 2011Article
- Activity-dependent release of endogenous BDNF from mossy fibers evokes a TRPC3 current and Ca2+ elevations in CA3 pyramidal neurons.Journal of neurophysiology · 2010Article
- Group I mGluR activation enhances Ca(2+)-dependent nonselective cation currents and rhythmic bursting in main olfactory bulb external tufted cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Activation of metabotropic glutamate receptors induces periodic burst firing and concomitant cytosolic Ca2+ oscillations in cerebellar interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transient receptor potential (TRP) channels form cationic channels activated by diverse factors including mechanical stimuli, changes in osmolarity, pH and temperature, as well as the exogenous irritant, capsaicin. Metabotropic glutamate receptors have also recently been linked to TRP channel activation in neurones of the substantia nigra, hippocampus and cerebellum, suggesting a novel role for such channels in synaptic communication via endogenous neurotransmitters. We tested this for dopamine neurones in rat brain slices by characterizing the current-voltage relationship and pharmacology of EPSCs mediated by group I metabotropic glutamate receptor subtype 1 (mGluR1). Slow inward currents (273 +/- 35 pA peak amplitude, 381 +/- 25 ms latency, holding potential (V(h)) =-73 mV) representing evoked mGluR1 EPSCs were isolated in the presence of antagonists of AMPA, NMDA, GABA(A), GABA(B), muscarinic and glycine receptors. CPCCOEt (100 microM), an mGluR1 antagonist, blocked the residual EPSC in all recordings. mGluR1-activated EPSCs reversed polarity near -10 mV, consistent with the involvement of a cationic channel. Extracellular application of the non-selective TRP channel blockers SKF 96365, flufenamic acid and ruthenium red caused reversible inhibition of mGluR1-activated EPSCs. These characteristics parallel those of mGluR1 activation with an agonist and indicate the involvement of a TRP-like channel in mGluR1-mediated EPSCs.
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