ArticleThe Journal of physiology2004
Calcium-induced calcium release regulates action potential generation in guinea-pig sympathetic neurones.
Article in The Journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- PDX1, a transcription factor essential for organ differentiation, regulates SERCA-dependent CaCell calcium · 2024Article
- BK Channel Regulation of Afterpotentials and Burst Firing in Cerebellar Purkinje Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Permethrin, a pyrethroid insecticide, regulates ERK1/2 activation through membrane depolarization-mediated pathway in HepG2 hepatocytes.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2018Article
- Ryanodine and IPNeurophotonics · 2017Article
- BK channels mediate dopamine inhibition of firing in a subpopulation of core nucleus accumbens medium spiny neurons.Brain research · 2014Article
- BK channels regulate sinoatrial node firing rate and cardiac pacing in vivo.American journal of physiology. Heart and circulatory physiology · 2014Article
- Somatic ATP release from guinea pig sympathetic neurons does not require calcium-induced calcium release from internal stores.American journal of physiology. Cell physiology · 2010Article
- Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity.Pharmacology & therapeutics · 2010Review
- Sigma receptor activation inhibits voltage-gated sodium channels in rat intracardiac ganglion neurons.International journal of physiology, pathophysiology and pharmacology · 2009Article
- Initial bradykinin triggers calcium-induced calcium release in C6 glioma cells and its significance.Neuroscience bulletin · 2009Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Experiments were done using guinea-pig sympathetic neurones dissociated from the stellate ganglia to establish whether calcium-induced calcium release (CICR) modulated action potential (AP) generation in mammalian neurones. Using measurements of intracellular calcium ([Ca(2+)](i)) with the Ca(2+)-sensitive dye fluo-3, we demonstrated that 10 mM caffeine activated ryanodine receptors and caused a rise in [Ca(2+)](i) in both Ca(2+)-containing and Ca(2+)-deficient solutions. We also demonstrated that combined treatment with caffeine and 1 microm thapsigargin or caffeine and 20 microm ryanodine blocked subsequent caffeine-induced elevations of [Ca(2+)](i). Treatment with thapsigargin, ryanodine or 200 microM Cd(2+) to disrupt CICR decreased the latency to AP generation during 400 ms depolarizing current ramps using the perforated patch whole cell patch clamp in current clamp mode. Treatment with 500 microM tetraethylammonium also decreased the latency to AP generation during depolarizing current ramps in control cells, but not in cells pretreated with thapsigargin to deplete internal Ca(2+) stores. In summary, we propose that an outward current, carried at least in part through BK channels, is activated by CICR at membrane voltages approaching the threshold for AP initiation and that this current opposed depolarizing current ramps applied to guinea-pig sympathetic stellate neurones.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.