Trial reportIntensive care medicine2004
Evaluation of a triple-lumen central venous heparin-coated catheter versus a catheter coated with chlorhexidine and silver sulfadiazine in critically ill patients.
Trial report in Intensive care medicine, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 5 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults.The Cochrane database of systematic reviews · 2022Pooled it
- Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults.The Cochrane database of systematic reviews · 2018Pooled it
- Catheter impregnation, coating or bonding for reducing central venous catheter-related infections in adults.The Cochrane database of systematic reviews · 2016Pooled it
- Heparin-bonded catheters for prolonging the patency of central venous catheters in children.The Cochrane database of systematic reviews · 2014Pooled it
- Anti-infective-treated central venous catheters: a systematic review of randomized controlled trials.Intensive care medicine · 2007Pooled it
- Effectiveness of antimicrobial-coated central venous catheters for preventing catheter-related blood-stream infections with the implementation of bundles: a systematic review and network meta-analysis.Annals of intensive care · 2018Review
- The Role of Antifungals against Candida Biofilm in Catheter-Related Candidemia.Antibiotics (Basel, Switzerland) · 2014Review
- Heparin-binding motifs and biofilm formation by Candida albicans.The Journal of infectious diseases · 2013Article
- Guidelines for the prevention of intravascular catheter-related infections.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2011Article
- Access technique and its problems in parenteral nutrition - Guidelines on Parenteral Nutrition, Chapter 9.German medical science : GMS e-journal · 2009Review
- Antimicrobial impregnated catheters in the prevention of catheter-related bloodstream infection in hospitalized patients.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2007Article
- Antiseptic-impregnated central venous catheters: their evaluation in burn patients.Annals of burns and fire disasters · 2006Article
- Year in review in intensive care medicine, 2004. I. Respiratory failure, infection, and sepsis.Intensive care medicine · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare the incidence of catheter colonization and catheter-related bloodstream infections between heparin-coated catheters and those coated with a synergistic combination of chlorhexidine and silver sulfadiazine.
designRandomized, controlled clinical trial.
settingA 20-bed medical-surgical intensive care unit. PATIENTS: A total of 180 patients requiring the insertion of a trilumen central venous catheter. INTERVENTIONS. Patients were randomized to receive either a trilumen heparin or chlorhexidine and silver sulfadiazine-coated catheter. MEASUREMENTS: Catheter colonization was defined by a semiquantitative catheter tip culture yielding 15 or more colony-forming units or quantitative culture of 1,000 or more colony-forming units/ml. Catheter-related bloodstream infection as the isolation of the same microorganism from a peripheral blood culture and catheter tip.
resultsA total of 260 catheters were cultured. Out of 132 heparin-coated catheters, 29 were colonized and out of 128 chlorhexidine and silver sulfadiazine-coated catheters, 13 were colonized ( p=0.03), relative risk RR=2.16 (1.18-3.97). This represents an incidence of 23.5 and 11.5 episodes of catheter colonization per 1,000 catheter-days, respectively ( p=0.0059), RR=2.04 (1.05-3.84). Microorganisms isolated in catheter colonization from heparin-coated catheters were gram-positive cocci 23, gram-negative bacilli 7, and Candida spp 4. In chlorhexidine and silver sulfadiazine-coated catheters were gram-positive cocci 6 and gram-negative bacilli 11 ( p=0.009). The incidence of catheter-related bloodstream infections per 1,000 catheter-days was 3.24 in heparin-coated catheters and 2.6 in chlorhexidine and silver sulfadiazine-coated catheters ( p=0.79), RR=1.22 (0.27-5.43).
conclusionsIn critically ill patients the use of trilumen central venous catheters coated with chlorhexidine and silver sulfadiazine reduced the risk of catheter colonization due to prevention of gram-positive cocci and Candida spp.
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