Evidence map›Paper›PMID 14722610›Full record

ReviewThe Journal of clinical investigation2004

Synapses and Sisyphus: life without paraplegin.

Harris A Gelbard

Open access · bronzeAbstract readReviewComment
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of clinical investigation, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Non-coding RNAs in the nervous system.The Journal of physiology · 2006
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Harris A GelbardDepartment of Neurology and the Center for Aging and Developmental Biology, University of Rochester Medical Center, Rochester, New York 14642, USA. Harris_Gelbard@urmc.rochester.edu
University of Rochester Medical Center · US

Funding

Targeted Neuro Protection of HIV-1 Associated Neurologic DiseaseP01MH064570 · NIMH · UNIVERSITY OF ROCHESTER · PI GELBARD, HARRIS A · 2001 to 2014
$19.4M
Role of EAAT2 and AEG-1 in Astrocyte Dysfunction and NeurodegenerationP01NS031492 · NINDS · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI GELBARD, HARRIS A · 1993 to 2007
$10.9M
ROLE OF PAF IN HIV-1 NEUROPATHOGENESISR01MH056838 · NIMH · UNIVERSITY OF ROCHESTER · PI GELBARD, HARRIS A · 1996 to 2014
$5.2M
NIMH NIH HHS P01 MH064570NIMH NIH HHS P01 MH64570NIMH NIH HHS R01 MH056838NIMH NIH HHS R01 MH56838NINDS NIH HHS P01 NS031492NINDS NIH HHS P01 NS31492
6 · The paper itself

Abstract

The family of neurodegenerative diseases known as hereditary spastic parapareses have diverse genetic loci, yet there is a remarkable convergence in the neuropathologic and neurologic phenotype. A report describing the construction of a transgenic mouse with a deletion of a nuclear-encoded mitochondrial protein involved in the regulation of oxidative phosphorylation suggests that this family of diseases may reflect activation of a final common pathway involving synaptic dysfunction that progresses to destruction of the presynaptic nerve terminal and axon.

Indexed as

AnimalsATPases Associated with Diverse Cellular ActivitiesCell NucleusGene DeletionHumansMembrane PotentialsMetalloendopeptidasesMiceMice, TransgenicMitochondriaModels, BiologicalOxidative StressOxygenPhenotypePhosphorylationSpastic Paraplegia, HereditaryATPases Associated with Diverse Cellular ActivitiesMetalloendopeptidasesOxygenSPG7 protein, humanSpg7 protein, mouse

Identifiers

PMID14722610
PMCPMC311441
OpenAlexW2051835928

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.