ArticleProceedings of the National Academy of Sciences of the United States of America2004
Paired-pulse depression of unitary quantal amplitude at single hippocampal synapses.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
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- Release Mode Dynamically Regulates the RRP Refilling Mechanism at Individual Hippocampal Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Presynaptic Inhibition of Primary Nociceptive Signals to Dorsal Horn Lamina I Neurons by Dopamine.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Regulation of Nociceptive Glutamatergic Signaling by Presynaptic Kv3.4 Channels in the Rat Spinal Dorsal Horn.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Array tomography of physiologically-characterized CNS synapses.Journal of neuroscience methods · 2016Article
- A Review on Locomotor Training after Spinal Cord Injury: Reorganization of Spinal Neuronal Circuits and Recovery of Motor Function.Neural plasticity · 2016Review
- Two-Photon Lifetime Imaging of Voltage Indicating Proteins as a Probe of Absolute Membrane Voltage.Biophysical journal · 2015Article
- Rapid genotyping of animals followed by establishing primary cultures of brain neurons.Journal of visualized experiments : JoVE · 2015Article
- Stiff substrates enhance cultured neuronal network activity.Scientific reports · 2014Article
- Bright and fast multicoloured voltage reporters via electrochromic FRET.Nature communications · 2014Article
- All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins.Nature methods · 2014Article
- Thalamic glutamatergic afferents into the rat basolateral amygdala exhibit increased presynaptic glutamate function following withdrawal from chronic intermittent ethanol.Neuropharmacology · 2013Article
- Upregulation of transmitter release probability improves a conversion of synaptic analogue signals into neuronal digital spikes.Molecular brain · 2012Article
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3 authors.
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Abstract
At central synapses, quantal size is generally regarded as fluctuating around a fixed mean with little change during short-term synaptic plasticity. We evoked quantal release by brief electric stimulation at single synapses visualized with FM 1-43 dye in hippocampal cultures. The majority of quantal events evoked at single synapses were monovesicular, based on examination of amplitude distribution of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-receptor-mediated responses. Consistent with previous findings, the quantal size did not change during paired-pulse facilitation (PPF), supporting the notion that the evoked events were monoquantal. However, during paired-pulse depression (PPD), there was a significant decrease in unitary quantal size, which was not due to postsynaptic receptor desensitization. This asymmetry of quantal modulation during PPF and PPD was demonstrated at the same single synapse at different extracellular calcium concentrations. Our results indicate that PPF can be fully accounted for by an increase of release probability, whereas PPD may be caused by decreases in both release probability and quantal size. One possible explanation is that the release of a quantum of neurotransmitter from synaptic vesicles is not invariant but subject to rapid calcium-dependent modulation during short-term synaptic plasticity.
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