ArticleJournal of virology2004
Astrovirus-induced synthesis of nitric oxide contributes to virus control during infection.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 48 citations in OpenAlex.
- Porcine astrovirus: a review.Archives of virology · 2026Review
- Murine astrovirus infection course and antibody response in different mouse strains.Lab animal · 2025Article
- Impact of duck astrovirus on susceptibility to infection across duck ages.Poultry science · 2024Article
- Structure and immunogenicity of the murine astrovirus capsid spike.The Journal of general virology · 2023Article
- Replication of Porcine Astrovirus Type 1-Infected PK-15 CellsMicrobiology spectrum · 2023Article
- An Insight into the Molecular Characteristics and Associated Pathology of Chicken Astroviruses.Viruses · 2022Review
- Pathogenesis of Chicken Astrovirus Related Illnesses.Frontiers in veterinary science · 2022Review
- Transcriptome Sequencing of the Spleen Reveals Antiviral Response Genes in Chickens Infected with CAstV.Viruses · 2021Article
- Article
- Characterizing a Murine Model for Astrovirus Using Viral Isolates from Persistently Infected Immunocompromised Mice.Journal of virology · 2019Article
- A radical form of nitric oxide inhibits porcine circovirus type 2 replication in vitro.BMC veterinary research · 2019Article
- Nitric oxide-generating compound GSNO suppresses porcine circovirus type 2 infection in vitro and in vivo.BMC veterinary research · 2017Article
- Review
- Development of a multiplex serological assay reveals a worldwide distribution of murine astrovirus infections in laboratory mice.PloS one · 2017Article
- The Immune Response to Astrovirus Infection.Viruses · 2016Review
- Activation of toll-like receptor signaling pathways leading to nitric oxide-mediated antiviral responses.Archives of virology · 2016Review
- Article
- Human astroviruses.Clinical microbiology reviews · 2014Review
- Adaptive immunity restricts replication of novel murine astroviruses.Journal of virology · 2012Article
- Characterization of turkey inducible nitric oxide synthase and identification of its expression in the intestinal epithelium following astrovirus infection.Comparative immunology, microbiology and infectious diseases · 2012Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Astrovirus is one of the major causes of infant and childhood diarrhea worldwide. Our understanding of astrovirus pathogenesis trails behind our knowledge of its molecular and epidemiologic properties. Using a recently developed small-animal model, we investigated the mechanisms by which astrovirus induces diarrhea and the role of both the adaptive and innate immune responses to turkey astrovirus type-2 (TAstV-2) infection. Astrovirus-infected animals were analyzed for changes in total lymphocyte populations, alterations in CD4(+)/CD8(+) ratios, production of virus-specific antibodies (Abs), and macrophage activation. There were no changes in the numbers of circulating or splenic lymphocytes or in CD4(+)/CD8(+) ratios compared to controls. Additionally, there was only a modest production of virus-specific Abs. However, adherent spleen cells from infected animals produced more nitric oxide (NO) in response to ex vivo stimulation with lipopolysaccharide. In vitro analysis demonstrated that TAstV-2 induced macrophage production of inducible nitric oxide synthase. Studies using NO donors and inhibitors in vivo demonstrated, for the first time, that NO inhibited astrovirus replication. These studies suggest that NO is important in limiting astrovirus replication and are the first, to our knowledge, to describe the potential role of innate immunity in astrovirus infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.