ArticleJournal of virology2004
Cell-dependent role for the poliovirus 3' noncoding region in positive-strand RNA synthesis.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Direct relationship between protein expression and progeny yield of herpes simplex virus 1.mBio · 2025Article
- Peroxisomes exhibit compromised structure and matrix protein content in SARS-CoV-2-infected cells.Molecular biology of the cell · 2021Article
- Article
- Emergency Services of Viral RNAs: Repair and Remodeling.Microbiology and molecular biology reviews : MMBR · 2018Review
- Identification of tell-tale patterns in the 3' non-coding region of hantaviruses that distinguish HCPS-causing hantaviruses from HFRS-causing hantaviruses.Emerging microbes & infections · 2018Article
- RSAD2 and AIM2 Modulate Coxsackievirus A16 and Enterovirus A71 Replication in Neuronal Cells in Different Ways That May Be Associated with Their 5' Nontranslated Regions.Journal of virology · 2018Article
- Functional Consequences of RNA 5'-Terminal Deletions on Coxsackievirus B3 RNA Replication and Ribonucleoprotein Complex Formation.Journal of virology · 2017Article
- Delayed kinetics of poliovirus RNA synthesis in a human cell line with reduced levels of hnRNP C proteins.Virology · 2010Article
- Mechanistic consequences of hnRNP C binding to both RNA termini of poliovirus negative-strand RNA intermediates.Journal of virology · 2010Article
- Attenuation of rabies virus replication and virulence by picornavirus internal ribosome entry site elements.Journal of virology · 2009Article
- Aichi virus 2A protein is involved in viral RNA replication.Journal of virology · 2008Article
- The cis-acting replication elements define human enterovirus and rhinovirus species.RNA (New York, N.Y.) · 2008Article
- 5' terminal deletions in the genome of a coxsackievirus B2 strain occurred naturally in human heart.Virology · 2008Article
- N-methylisatin-beta-thiosemicarbazone derivative (SCH 16) is an inhibitor of Japanese encephalitis virus infection in vitro and in vivo.Virology journal · 2008Article
- Genetic adaptation to untranslated region-mediated enterovirus growth deficits by mutations in the nonstructural proteins 3AB and 3CD.Journal of virology · 2007Article
- Epidemics to eradication: the modern history of poliomyelitis.Virology journal · 2007Review
- Breaking pseudo-twofold symmetry in the poliovirus 3'-UTR Y-stem by restoring Watson-Crick base pairs.RNA (New York, N.Y.) · 2007Article
- A hypervariable region within the 3' cis-acting element of the murine coronavirus genome is nonessential for RNA synthesis but affects pathogenesis.Journal of virology · 2007Article
- A pseudoknot in a preactive form of a viral RNA is part of a structural switch activating minus-strand synthesis.Journal of virology · 2006Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
We previously reported the isolation of a mutant poliovirus lacking the entire genomic RNA 3' noncoding region. Infection of HeLa cell monolayers with this deletion mutant revealed only a minor defect in the levels of viral RNA replication. To further analyze the consequences of the genomic 3' noncoding region deletion, we examined viral RNA replication in a neuroblastoma cell line, SK-N-SH cells. The minor genomic RNA replication defect in HeLa cells was significantly exacerbated in the SK-N-SH cells, resulting in a decreased capacity for mutant virus growth. Analysis of the nature of the RNA replication deficiency revealed that deleting the poliovirus genomic 3' noncoding region resulted in a positive-strand RNA synthesis defect. The RNA replication deficiency in SK-N-SH cells was not due to a major defect in viral translation or viral protein processing. Neurovirulence of the mutant virus was determined in a transgenic mouse line expressing the human poliovirus receptor. Greater than 1,000 times more mutant virus was required to paralyze 50% of inoculated mice, compared to that with wild-type virus. These data suggest that, together with a cellular factor(s) that is limiting in neuronal cells, the poliovirus 3' noncoding region is involved in positive-strand synthesis during genome replication.
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Registered trials
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