ArticleJournal of virology2004
The pseudorabies virus US3 protein is a component of primary and of mature virions.
Article in Journal of virology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 62 citations in OpenAlex.
- Molecular plasticity of herpesvirus nuclear egress analysed in situ.Nature microbiology · 2024Article
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- HSV-1 Cytoplasmic Envelopment and Egress.International journal of molecular sciences · 2020Review
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- Phosphorylation of Bovine Herpesvirus 1 VP8 Plays a Role in Viral DNA Encapsidation and Is Essential for Its Cytoplasmic Localization and Optimal Virion Incorporation.Journal of virology · 2016Article
- Gammaherpesvirus Tegument Protein ORF33 Is Associated With Intranuclear Capsids at an Early Stage of the Tegumentation Process.Journal of virology · 2015Article
- Herpes simplex virus 1 Us3 deletion mutant is infective despite impaired capsid translocation to the cytoplasm.Viruses · 2015Article
- Herpes simplex virus 1 UL47 interacts with viral nuclear egress factors UL31, UL34, and Us3 and regulates viral nuclear egress.Journal of virology · 2014Article
- Analysis of the early steps of herpes simplex virus 1 capsid tegumentation.Journal of virology · 2013Article
- Herpesvirus transport to the nervous system and back again.Annual review of microbiology · 2012Review
- The salivary secretome of the tsetse fly Glossina pallidipes (Diptera: Glossinidae) infected by salivary gland hypertrophy virus.PLoS neglected tropical diseases · 2011Article
- A physical link between the pseudorabies virus capsid and the nuclear egress complex.Journal of virology · 2011Article
- Identification of interaction domains within the UL37 tegument protein of herpes simplex virus type 1.Virology · 2011Article
- Proteomic characterization of pseudorabies virus extracellular virions.Journal of virology · 2011Article
- Role of tegument proteins in herpesvirus assembly and egress.Protein & cell · 2010Review
- Random transposon-mediated mutagenesis of the essential large tegument protein pUL36 of pseudorabies virus.Journal of virology · 2010Article
- The major determinant for addition of tegument protein pUL48 (VP16) to capsids in herpes simplex virus type 1 is the presence of the major tegument protein pUL36 (VP1/2).Journal of virology · 2010Article
- Intracellular localization of the pseudorabies virus large tegument protein pUL36.Journal of virology · 2009Article
- Expression and characterization of the UL31 protein from duck enteritis virus.Virology journal · 2009Article
- Differing roles of inner tegument proteins pUL36 and pUL37 during entry of herpes simplex virus type 1.Journal of virology · 2009Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herpesviruses acquire a primary envelope by budding of capsids at the inner leaflet of the nuclear membrane. They then traverse into the cytoplasm after fusion of the primary envelope with the outer leaflet of the nuclear membrane. In the alphaherpesvirus pseudorabies virus (PrV), the latter process is impaired when the US3 protein is absent. Acquisition of final tegument and envelope occurs in the cytoplasm. Besides the capsid components, only the UL31 and UL34 gene products of PrV have unequivocally been shown to be part of primary enveloped virions, whereas they lack several tegument proteins present in mature virions (reviewed by T. C. Mettenleiter, J. Virol. 76:1537-1547, 2002). Using immunoelectron microscopy, we show that the US3 protein is present in primary enveloped as well as in mature virions. It is also detectable in intracytoplasmic inclusions produced in the absence of other viral tegument components or envelope-associated glycoproteins. In particular, inclusions formed in the absence of the inner tegument protein UL37 contained the US3 protein. Thus, the US3 protein is a tegument component of both forms of enveloped alphaherpes virions. We hypothesize that US3 protein in primary virions modulates deenvelopment at the outer leaflet of the nuclear membrane and is either lost from primary virions during nuclear egress and subsequently reacquired early during tegumentation or is retained during transit of the nucleocapsid through the nuclear membrane.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.