ArticleCancer science2004
Vaccination with autologous endothelium inhibits angiogenesis and metastasis of colon cancer through autoimmunity.
Article in Cancer science, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 59 citations in OpenAlex.
- Antigenic Essence: Upgrade of Cellular Cancer Vaccines.Cancers · 2021Review
- Combination of vasculature targeting, hypofractionated radiotherapy, and immune checkpoint inhibitor elicits potent antitumor immune response and blocks tumor progression.Journal for immunotherapy of cancer · 2021Article
- Allogenic mouse cell vaccine inhibits lung cancer progression by inhibiting angiogenesis.Human vaccines & immunotherapeutics · 2021Article
- SANTAVACVaccines · 2019Review
- Article
- SANTAVAC ™: A Novel Universal Antigen Composition for Developing Cancer Vaccines.Recent patents on biotechnology · 2017Article
- Dendritic cells loading autologous tumor lysate promote tumor angiogenesis.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Insight to drug delivery aspects for colorectal cancer.World journal of gastroenterology · 2016Review
- Cancer anti-angiogenesis vaccines: Is the tumor vasculature antigenically unique?Journal of translational medicine · 2015Review
- Targeting the tumor vasculature to enhance T cell activity.Current opinion in immunology · 2015Review
- Design of universal cancer vaccines using natural tumor vessel-specific antigens (SANTAVAC).Human vaccines & immunotherapeutics · 2015Review
- Tumor endothelial marker 1-specific DNA vaccination targets tumor vasculature.The Journal of clinical investigation · 2014Article
- Enhanced antitumor efficacy by combination treatment with a human umbilical vein endothelial cell vaccine and a tumor cell lysate-based vaccine.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- Improved efficacy of therapeutic vaccination with viable human umbilical vein endothelial cells against murine melanoma by introduction of OK432 as adjuvant.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Article
- Therapeutic antitumor potential of endoglin-based DNA vaccine combined with immunomodulatory agents.Gene therapy · 2013Article
- Tumor-induced endothelial cell surface heterogeneity directly affects endothelial cell escape from a cell-mediated immune response in vitro.Human vaccines & immunotherapeutics · 2013Article
- Cancer microenvironment and cancer vaccine.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2012Article
- Vaccines targeting tumor blood vessel antigens promote CD8(+) T cell-dependent tumor eradication or dormancy in HLA-A2 transgenic mice.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Anti-angiogenesis immunotherapy.Human vaccines · 2011Article
- Intratumoral IL-12 gene therapy results in the crosspriming of Tc1 cells reactive against tumor-associated stromal antigens.Molecular therapy : the journal of the American Society of Gene Therapy · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Overcoming immune tolerance of tumor angiogenesis should be useful for adjuvant therapy of cancer. We hypothesized that vaccination with autologous endothelium would induce an autoimmune response targeting tumor angiogenesis. To test this concept, we immunized BALB/c mice with a vaccine of glutaraldehyde-fixed murine hepatic sinusoidal endothelial cells (HSEs) in a lung metastasis model of Colon-26 cancer. Vaccination with autologous HSEs induced both preventive and therapeutic anti-tumor immunity that significantly inhibited the development of metastases. ELISA revealed an immunoglobulin response involving IgM and IgG subclasses. These antibodies had a strong affinity for antigens of both murine and human endothelium, and lyzed endothelial cells in the CDC assay. Flow-cytometry and chromium-release cytotoxicity assay revealed a specific CTL response against endothelial cells, which were lyzed in an effector: target ratio-dependent manner. Neither antibodies nor CTLs reacted with Colon-26. The effect of autologous HSEs was more pronounced than that of xenogeneic human umbilical vein endothelial cells (HUVECs), which were tested in the same experimental setting. Our results suggest that vaccination with autologous endothelium can overcome peripheral tolerance of self-angiogenic antigens and therefore should be useful for adjuvant immunotherapy of cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.