ArticleNeuropathology and applied neurobiology2004
The p53 homologue p73 accumulates in the nucleus and localizes to neurites and neurofibrillary tangles in Alzheimer disease brain.
Article in Neuropathology and applied neurobiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 36 citations in OpenAlex.
- Biological Hallmarks of Cancer in Alzheimer's Disease.Molecular neurobiology · 2019Review
- How Does p73 Cause Neuronal Defects?Molecular neurobiology · 2016Review
- p53 prevents neurodegeneration by regulating synaptic genes.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Cooperative role of RanBP9 and P73 in mitochondria-mediated apoptosis.Cell death & disease · 2013Article
- UBE4B: a promising regulatory molecule in neuronal death and survival.International journal of molecular sciences · 2012Review
- Mammary epithelial cell polarity is regulated differentially by p73 isoforms via epithelial-to-mesenchymal transition.The Journal of biological chemistry · 2012Article
- Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Complex regulation of p73 isoforms after alteration of amyloid precursor polypeptide (APP) function and DNA damage in neurons.The Journal of biological chemistry · 2011Article
- p73: a multifunctional protein in neurobiology.Molecular neurobiology · 2011Review
- Analysis of the intracellular localization of p73 N-terminal protein isoforms TAp73 and ∆Np73 in medulloblastoma cell lines.Journal of molecular histology · 2010Article
- No more brain tangles with DeltaNp73.Trends in biochemical sciences · 2009Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The molecular mechanisms that regulate neuronal survival vs. death during Alzheimer disease (AD) remain unclear. Nonetheless, a number of recent studies indicate that increased expression or altered subcellular distribution of numerous cell cycle proteins during AD may contribute to disease pathogenesis. Because homologues of p53, a key regulatory protein in the cell cycle, such as p73, have been identified and shown to participate in cellular differentiation and death pathways, we examined the expression and distribution of p73 in the hippocampus of eight control and 16 AD subjects. In control subjects, hippocampal pyramidal neurones exhibit p73 immunoreactivity that is distributed predominately in the cytoplasm. In AD hippocampus, increased levels of p73 are located in the nucleus of pyramidal neurones and p73 is located in dystrophic neurites and cytoskeletal pathology. Immunoblot analysis confirmed the presence of p73 in the hippocampus. These data indicate that p73 is expressed within hippocampal pyramidal neurones and exhibits altered subcellular distribution in AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.