ArticleMolecular biology of the cell2004
Transcription of Drosophila troponin I gene is regulated by two conserved, functionally identical, synergistic elements.
Article in Molecular biology of the cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- High-density SNP-based linkage map construction and QTL analysis for growth-related traits inFrontiers in genetics · 2025Article
- The haplolethality paradox of the wupA gene in Drosophila.PLoS genetics · 2021Article
- Review
- CF2 transcription factor is involved in the regulation of Mef2 RNA levels, nuclei number and muscle fiber size.PloS one · 2017Article
- Article
- Troponin-I enhances and is required for oncogenic overgrowth.Oncotarget · 2016Article
- Article
- Article
- Expression of the Troponin C at 41C Gene in Adult Drosophila Tubular Muscles Depends upon Both Positive and Negative Regulatory Inputs.PloS one · 2015Article
- Roles of the troponin isoforms during indirect flight muscle development in Drosophila.Journal of genetics · 2014Article
- Transcriptional networks regulating the costamere, sarcomere, and other cytoskeletal structures in striated muscle.Cellular and molecular life sciences : CMLS · 2014Review
- Differential requirements for Myocyte Enhancer Factor-2 during adult myogenesis in Drosophila.Developmental biology · 2012Article
- CF2 represses Actin 88F gene expression and maintains filament balance during indirect flight muscle development in Drosophila.PloS one · 2010Article
- Cardiac gene regulatory networks in Drosophila.Biochimica et biophysica acta · 2009Review
- Mitochondrial transcription factor B2 is essential for metabolic function in Drosophila melanogaster development.The Journal of biological chemistry · 2008Article
- Myocyte enhancer factor 2 and chorion factor 2 collaborate in activation of the myogenic program in Drosophila.Molecular and cellular biology · 2008Article
- Transcriptional regulation of the Drosophila melanogaster muscle myosin heavy-chain gene.Gene expression patterns : GEP · 2007Article
- Adult myogenesis in Drosophila melanogaster can proceed independently of myocyte enhancer factor-2.Genetics · 2005Article
- Article
- Overexpression of troponin T in Drosophila muscles causes a decrease in the levels of thin-filament proteins.The Biochemical journal · 2005Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Drosophila wings-up A gene encodes Troponin I. Two regions, located upstream of the transcription initiation site (upstream regulatory element) and in the first intron (intron regulatory element), regulate gene expression in specific developmental and muscle type domains. Based on LacZ reporter expression in transgenic lines, upstream regulatory element and intron regulatory element yield identical expression patterns. Both elements are required for full expression levels in vivo as indicated by quantitative reverse transcription-polymerase chain reaction assays. Three myocyte enhancer factor-2 binding sites have been functionally characterized in each regulatory element. Using exon specific probes, we show that transvection is based on transcriptional changes in the homologous chromosome and that Zeste and Suppressor of Zeste 3 gene products act as repressors for wings-up A. Critical regions for transvection and for Zeste effects are defined near the transcription initiation site. After in silico analysis in insects (Anopheles and Drosophila pseudoobscura) and vertebrates (Ratus and Coturnix), the regulatory organization of Drosophila seems to be conserved. Troponin I (TnI) is expressed before muscle progenitors begin to fuse, and sarcomere morphogenesis is affected by TnI depletion as Z discs fail to form, revealing a novel developmental role for the protein or its transcripts. Also, abnormal stoichiometry among TnI isoforms, rather than their absolute levels, seems to cause the functional muscle defects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.