ArticleMolecular biology of the cell2004
The transcriptome of prematurely aging yeast cells is similar to that of telomerase-deficient cells.
Article in Molecular biology of the cell, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 124 citations in OpenAlex.
- Article
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- Chromatin balances cell redox and energy homeostasis.Epigenetics & chromatin · 2023Review
- Transcriptional drift in aging cells: A global de-controller.bioRxiv : the preprint server for biology · 2023Article
- Senescence in yeast is associated with amplified linear fragments of chromosome XII rather than ribosomal DNA circle accumulation.PLoS biology · 2023Article
- Dietary change without caloric restriction maintains a youthful profile in ageing yeast.PLoS biology · 2023Article
- Tra1 controls the transcriptional landscape of the aging cell.G3 (Bethesda, Md.) · 2023Article
- Multifarious Translational Regulation during Replicative Aging in Yeast.Journal of fungi (Basel, Switzerland) · 2022Article
- Proteasome Activator Blm10 Regulates Transcription Especially During Aging.Current genomics · 2021Article
- Anti-bias training for (sc)RNA-seq: experimental and computational approaches to improve precision.Briefings in bioinformatics · 2021Article
- Article
- Replicative Aging in Pathogenic Fungi.Journal of fungi (Basel, Switzerland) · 2020Review
- Insights into the Conserved Regulatory Mechanisms of Human and Yeast Aging.Biomolecules · 2020Review
- Trajectories of Aging: How Systems Biology in Yeast Can Illuminate Mechanisms of Personalized Aging.Proteomics · 2020Review
- Epigenetic changes during aging and their reprogramming potential.Critical reviews in biochemistry and molecular biology · 2019Review
- Gene expression hallmarks of cellular ageing.Biogerontology · 2018Review
- Advancing the aging biology toolkit.eLife · 2018Article
- Article
- Article
- Emerging Omics Approaches in Aging Research.Antioxidants & redox signaling · 2018Review
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
To help define the pathologies associated with yeast cells as they age, we analyzed the transcriptome of young and old cells isolated by elutriation, which allows isolation of biochemical quantities of old cells much further advanced in their life span than old cells prepared by the biotin-streptavidin method. Both 18-generation-old wild-type yeast and 8-generation-old cells from a prematurely aging mutant (dna2-1), with a defect in DNA replication, were evaluated. Genes involved in gluconeogenesis, the glyoxylate cycle, lipid metabolism, and glycogen production are induced in old cells, signifying a shift toward energy storage. We observed a much more extensive generalized stress response known as the environmental stress response (ESR), than observed previously in biotin-streptavidin-isolated cells, perhaps because the elutriated cells were further advanced in their life span. In addition, there was induction of DNA repair genes that fall in the so-called DNA damage "signature" set. In the dna2-1 mutant, energy production genes were also induced. The response in the dna2-1 strain is similar to the telomerase delete response, genes whose expression changes during cellular senescence in telomerase-deficient cells. We propose that these results suggest, albeit indirectly, that old cells are responding to genome instability.
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