ReviewDrug safety2004
Comparative tolerability of sedative agents in head-injured adults.
Review in Drug safety, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Anesthetic management of unruptured intracranial aneurysms: a qualitative systematic review.Neurosurgical review · 2021Pooled it
- Ketamine does not increase intracranial pressure compared with opioids: meta-analysis of randomized controlled trials.Journal of anesthesia · 2014Pooled it
- Sedation for moderate-to-severe traumatic brain injury in adults.The Cochrane database of systematic reviews · 2025Article
- Efficacy of Ketamine as an Adjuvant to Scalp Block for Hemodynamic Stability in Patients Undergoing Elective Craniotomy for Supratentorial Glioma: A Prospective Randomized Controlled Trial.Asian journal of neurosurgery · 2024Article
- Comparison of Midazolam and Propofol Infusion to Suppress Stress Response in Patients With Severe Traumatic Brain Injury: A Prospective, Randomized Controlled Trial.Korean journal of neurotrauma · 2023Article
- Are GABAergic drugs beneficial in providing neuroprotection after traumatic brain injuries? A comprehensive literature review of preclinical studies.Frontiers in neurology · 2023Review
- Early sedation in traumatic brain injury: a multicentre international observational study.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2022Article
- Article
- Posttraumatic midazolam administration does not influence brain damage after experimental traumatic brain injury.BMC anesthesiology · 2022Article
- A One-Day Prospective National Observational Study on Sedation-Analgesia of Patients with Brain Injury in French Intensive Care Units: The SEDA-BIP-ICU (Sedation-Analgesia in Brain Injury Patient in ICU) Study.Neurocritical care · 2022Observational
- Effect of Dezocine on Hemodynamic Indexes of Postoperative Patients With Traumatic Brain Injury (TBI)---A Pilot Study.Frontiers in pharmacology · 2022Article
- Is jugular bulb oximetry monitoring associated with outcome in out of hospital cardiac arrest patients?Journal of clinical monitoring and computing · 2021Observational
- Association Between Processed Electroencephalogram-Based Objectively Measured Depth of Sedation and Cerebrovascular Response: A Systematic Scoping Overview of the Human and Animal Literature.Frontiers in neurology · 2021Review
- Effect of sedative agent selection on morbidity, mortality and length of stay in patients with increase in intracranial pressure.World journal of emergency medicine · 2018Article
- Optimizing sedation in patients with acute brain injury.Critical care (London, England) · 2016Review
- The emerging use of ketamine for anesthesia and sedation in traumatic brain injuries.CNS neuroscience & therapeutics · 2013Review
- Sedation in traumatic brain injury.Emergency medicine international · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sedative agents are widely used in the management of patients with head injury. These drugs can facilitate assisted ventilation and may provide useful reductions in cerebral oxygen demand. However, they may compromise cerebral oxygen delivery via their cardiovascular effects. In addition, individual sedative agents have specific and sometimes serious adverse effects. This review focuses on the different classes of sedative agents used in head injury, with a discussion of their role in the context of clinical pathophysiology. While there is no sedative that has all the desirable characteristics for an agent in this clinical setting, careful titration of dose, combination of agents, and a clear understanding of the pathophysiology and pharmacology of these agents will allow safe sedative administration in head injury.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.