ArticleWorld journal of gastroenterology2004
Expression of estrogen receptor beta in human colorectal cancer.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- Estradiol Reshapes Cell-Type-Dependent Basal Redox Set-Points in Colorectal Carcinoma Cells.Biomedicines · 2026Article
- β-glucuronidase: potential target for postmenopausal gut dysbiosis in Estrogen deficient chronic unpredictable mild stressed rats.Molecular biology reports · 2026Article
- Sex steroid receptors in colorectal cancer: implications for tumor progression, therapeutic opportunities, and sex-specific outcomes.Annals of medicine and surgery (2012) · 2026Review
- Review
- Implications of estrogen and its receptors in colorectal carcinoma.Cancer medicine · 2023Review
- Combined Estrogen Alpha and Beta Receptor Expression Has a Prognostic Significance for Colorectal Cancer Patients.Frontiers in medicine · 2022Article
- Estrogen Receptors in Colorectal Cancer: Facts, Novelties and Perspectives.Current oncology (Toronto, Ont.) · 2021Article
- Targeting estrogen receptors in colorectal cancer.Molecular biology reports · 2020Review
- Estrogen and Progesterone Expression in Colorectal Carcinoma: A Clinicopathological Study.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Expression and Prognostic Value of Oestrogen Receptor Beta in Colorectal Cancer.Pathology oncology research : POR · 2018Article
- mRNA expression of steroidogenic enzymes, steroid hormone receptors and their coregulators in gastric cancer.Oncology letters · 2017Article
- Estrogen receptor beta as target for colorectal cancer prevention.Cancer letters · 2016Review
- Associations between Environmental Exposures and Incident Colorectal Cancer by ESR2 Protein Expression Level in a Population-Based Cohort of Older Women.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2015Article
- Estrogen receptors and their implications in colorectal carcinogenesis.Frontiers in oncology · 2015Review
- Chemopreventive efficacy of raloxifene, bexarotene, and their combination on the progression of chemically induced colon adenomas to adenocarcinomas in rats.Cancer prevention research (Philadelphia, Pa.) · 2013Article
- The cervical malignant cells display a down regulation of ER-α but retain the ER-β expression.International journal of clinical and experimental pathology · 2013Article
- Potential value of estrogen receptor beta expression in colorectal carcinoma: interaction with apoptotic index.Journal of gastrointestinal cancer · 2012Article
- Cyclin D1 expression in colorectal cancer is a favorable prognostic factor in men but not in women in a prospective, population-based cohort study.Biology of sex differences · 2011Article
- G protein-coupled receptor kinase 5 mediates Tazarotene-induced gene 1-induced growth suppression of human colon cancer cells.BMC cancer · 2011Article
- Gender-specific genomic profiling in metastatic colorectal cancer patients treated with 5-fluorouracil and oxaliplatin.Pharmacogenomics · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine the expression of estrogen receptor (ER) beta in Chinese colorectal carcinoma (CRC) patients.
methodsERbeta expression in CRC was investigated by immunohistochemical staining of formalin-fixed, paraffin-embedded tissue sections from 40 CRCs, 10 colonic adenomas, and 10 normal colon mucosa biopsies. The percentage of positive cells was recorded, mRNA expression of ERalpha and ERbeta in 12 CRC tissues and paired normal colon tissues were detected by RT-PCR.
resultsPositive ER immunoreactivity was present in part of normal epithelium of biopsy (2/10), adenomas (3/10), and the sections of CRC tissue, most of them were nuclear positive. In CRCs, nuclear ERbeta immunoreactivity was detected in over 10% of the cancer cells in 57.5% of the cases and was always associated with cytoplasmic immunoreactivity. There was no statistical significance between ERbeta positive and negative groups in regard to depth of invasion and nodal metastases. Of the 12 CRC tissues and paired normal colon tissues, the expression rate of ERalpha mRNA in CRC tissue and corresponding normal colon tissue was 25% and 16.6%, respectively. ERbeta mRNA was expressed in 83.3% CRC tissue and 91.7% paired normal colon tissue, respectively. There was no significant difference in ERbeta mRNA level between CRC tissues and paired normal colon tissues.
conclusionA large number of CRCs are positive for ERbeta, which can also be detected in normal colonic epithelia. There is a different localization of ERbeta immunoreactivity among normal colon mucosae, adenomas and CRCs. ERalpha and ERbeta mRNA can be detected both in CRC tissue and in corresponding normal colon tissue. A post-transcriptional mechanism may account for the decrease of ERbeta protein expression in CRC tissues.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.