ArticleWorld journal of gastroenterology2004
Effects of p53 on apoptosis and proliferation of hepatocellular carcinoma cells treated with transcatheter arterial chemoembolization.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Transarterial (chemo)embolization for curative resection of hepatocellular carcinoma: a systematic review and meta-analyses.Journal of cancer research and clinical oncology · 2014Pooled it
- Meta-analysis: preoperative transcatheter arterial chemoembolization does not improve prognosis of patients with resectable hepatocellular carcinoma.BMC gastroenterology · 2013Pooled it
- Preoperative hepatic and regional arterial chemotherapy in the prevention of liver metastasis after colorectal cancer surgery.Annals of surgery · 2007Trial
- Hepatocellular carcinoma: tumor heterogeneity and recurrence after preoperative locoregional therapy.Medical oncology (Northwood, London, England) · 2023Article
- Verification of neuroprotective effects of alpha-lipoic acid on chronic neuropathic pain in a chronic constriction injury rat model.Open life sciences · 2021Article
- Article
- Investigating genetic characteristics of hepatitis B virus-associated and -non-associated hepatocellular carcinoma.Genetics research · 2016Article
- Silymarin inhibited proliferation and induced apoptosis in hepatic cancer cells.Cell proliferation · 2009Article
- Effect of preoperative transcatheter arterial chemoembolization on proliferation of hepatocellular carcinoma cells.World journal of gastroenterology · 2007Article
- Preoperative Locoregional Therapy May Relate with Stemness and Distinct Transitions Between Epithelial and Mesenchymal States in Hepatocellular Carcinoma.Journal of clinical and experimental hepatologyArticle
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3 authors.
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Abstract
aimTo evaluate the effects of p53 on apoptosis and proliferation of hepatocellular carcinoma (HCC) cells treated with transcatheter arterial chemoembolization (TACE).
methodsA total of 136 patients with HCC received TACE and other management before surgery were divided into TACE group and non-TACE group. TACE group included 79 patients who had 1-5 courses of TACE before surgery, of them, 11 patients had 1-4 courses of chemotherapy (group A), 33 patients had 1-5 courses of chemotherapy combined with iodized oil (group B), 23 patients had 1-3 courses of chemotherapy, iodized oil and gelatin sponge (group C), 12 patients had 1-3 courses of chemotherapy combined with iodized oil, ethanol and gelatin sponge (group D). Non-TACE group included the remaining 57 patients who had surgery only. The extent of apoptosis was analyzed by transferase mediated dUTP nick end labeling (TUNEL) staining. The expressions of p53, Bcl-2, Bax, Ki-67 and PCNA protein were detected by immunohistochemical method.
resultsP53 protein expressions in trabecular and clear cells in HCC specimens were significantly lower than that in pseudoglandular, solid, poorly differentiated or undifferentiated and sclerosis HCC (P<0.05). Expression of p53 protein in HCC cells increased with the increase of pathological grades (P<0.05), and correlated positively with expressions of Ki-67 and PCNA protein, and negatively with Bcl-2 to Bax protein expression rate and AI (P<0.05). Expression of p53 protein was significantly higher in group A than in groups B, C, D and the non-TACE group, and was higher in group B than in groups C and D, and lower in group D than in the non-TACE group (P<0.05).
conclusionExpression of p53 protein can enhance proliferation of HCC cells and suppress apoptosis of HCC cells after TACE.
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