ArticleWorld journal of gastroenterology2004
Expression of NF-kappaB and human telomerase reverse transcriptase in gastric cancer and precancerous lesions.
Article in World journal of gastroenterology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Cellular senescence in cancer: Unveiling dual roles, tumor microenvironment dynamics and therapeutic innovations (Review).Oncology letters · 2025Review
- Research progress on the therapeutic effects of effective components of traditional Chinese medicine in the treatment of gastric cancer precursors through modulation of multiple signaling pathways.Frontiers in oncology · 2025Review
- NF-κB in Gastric Cancer Development and Therapy.Biomedicines · 2021Review
- FEZF1-AS1: a novel vital oncogenic lncRNA in multiple human malignancies.Bioscience reports · 2019Review
- HER2, NF-Disease markers · 2019Article
- RAGE and Its Ligands: Molecular Interplay Between Glycation, Inflammation, and Hallmarks of Cancer-a Review.Hormones & cancer · 2018Review
- NF-κB Signaling in Gastric Cancer.Toxins · 2017Review
- MOXIBUSTION ALLEVIATES GASTRIC PRECANCEROUS LESIONS IN RATS BY PROMOTING CELL APOPTOSIS AND INHIBITING PROLIFERATION-RELATED ONCOGENES.African journal of traditional, complementary, and alternative medicines : AJTCAM · 2017Article
- The correlation between miRNA and lymph node metastasis in gastric cancer.BioMed research international · 2015Article
- Telomerase and hTERT: can they serve as markers for gastric cancer diagnosis?World journal of gastroenterology · 2014Article
- A phase I trial of bortezomib in combination with epirubicin, carboplatin and capecitabine (ECarboX) in advanced oesophagogastric adenocarcinoma.Investigational new drugs · 2014Article
- Activation of the NF-kB pathway downregulates TFF-1 in gastric carcinogenesis.Virchows Archiv : an international journal of pathology · 2013Article
- hTERT and TP53 deregulation in intestinal-type gastric carcinogenesis in non-human primates.Clinical and experimental medicine · 2013Article
- Circulating cell-free human telomerase reverse transcriptase mRNA in plasma and its potential diagnostic and prognostic value for gastric cancer.International journal of clinical oncology · 2013Article
- Imbalanced network biomarkers for traditional Chinese medicine Syndrome in gastritis patients.Scientific reports · 2013Article
- hTERT, MYC and TP53 deregulation in gastric preneoplastic lesions.BMC gastroenterology · 2012Article
- Prognostic role of telomerase activity in gastric adenocarcinoma: A meta-analysis.Experimental and therapeutic medicine · 2012Article
- IkappaBalpha polymorphism at promoter region (rs2233408) influences the susceptibility of gastric cancer in Chinese.BMC gastroenterology · 2010Article
- Investigation into the controversial association of Streptococcus gallolyticus with colorectal cancer and adenoma.BMC cancer · 2009Article
- Nuclear factor kappa B: a marker of chemotherapy for human stage IV gastric carcinoma.World journal of gastroenterology · 2008Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the expression of NF-kappaBp65 protein and human telomerase reverse transcriptase (hTERT) and their correlation in gastric cancer and precancerous lesions.
methodsForty-one patients with primary gastric cancer, 15 with dysplasia, 23 intestinal metaplasia and 10 with normal gastric mucosa were included in this study. Expression of NF-kappaBp65 protein, hTERT mRNA and protein were determined by immunohistochemistry and in situ hybridization.
resultsThe rate of p65 expression in normal gastric mucosa, intestinal metaplasia, dysplasia and carcinoma was 0%, 34.78%, 53.33% and 60.98%, respectively, while the rate of hTERT mRNA expression was 10.00%, 39.13%, 66.67% and 85.37% and the rate of hTERT protein expression was 0%, 30.43%, 60.00% and 78.05%, respectively. All the three parameters were significantly increased in dysplasia and carcinoma compared to normal mucosa, while the expression levels were also significantly higher in carcinoma than in intestinal metaplasia (P<0.05). In gastric cancer tissues, nuclear staining rates of p65 and hTERT protein were both significantly associated with the degree of differentiation, lymph node metastasis, clinical stage and invasion depth (P<0.05). However, hTERT mRNA expression was only significantly associated with clinical stage. There was a positive correlation between p65 and hTERT mRNA (rs=0.661-0.752, P<0.01), and between hTERT protein and hTERT mRNA (rs=0.609-0.750, P<0.01).
conclusionNF-kappaBp65 and hTERT expressions are upregulated at the early stage of gastric carcinogenesis. NF-kappaB activation may contribute to hTERT expression and thereby enhance telomerase activity, which represents an important step in carcinogenesis progress.
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