ReviewReviews in medical virology
Rhinovirus and the lower respiratory tract.
Review in Reviews in medical virology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05962645 (A Phase 1 Study to Confirm the Single- and Multiple-dose Pharmacokinetics and to Evaluate Food Effect of Vapendavir in Healthy Participants and Participants With COPD), which is not on this map. Cited by 127 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase 1 Study to Confirm the Single- and Multiple-dose Pharmacokinetics and to Evaluate Food Effect of Vapendavir in Healthy Participants and Participants With COPD
Who cites it
127 citing papers in PubMed, 2 syntheses or guidelines pooled it, 260 citations in OpenAlex.
- Incidence of viral infection detected by PCR and real-time PCR in childhood community-acquired pneumonia: a meta-analysis.Respirology (Carlton, Vic.) · 2015Pooled it
- 2007 Guideline for Isolation Precautions: Preventing Transmission of Infectious Agents in Health Care Settings.American journal of infection control · 2007Guideline
- Trial
- Trial
- Structural insights into the antiviral efficacy of AG7404 against human rhinovirus 3C proteases.IUCrJ · 2026Article
- Temperature-Dependent Viral Pathogenicity: Implications for Attenuation of Viral Vaccines.Viruses · 2025Review
- Genotypic Diversity of Human Rhinovirus in Children with Pneumonia Before and During the COVID-19 Pandemic in Mexico.Pathogens (Basel, Switzerland) · 2025Article
- Article
- Review
- The impact of non-pharmaceutical interventions on community non-SARS-CoV-2 respiratory infections in preschool children.BMC pediatrics · 2024Article
- Article
- Establishment of RT-RPA-Cas12a assay for rapid and sensitive detection of human rhinovirus B.BMC microbiology · 2023Article
- Antiviral and antimicrobial applications of chalcones and their derivatives: From nature to greener synthesis.Heliyon · 2023Review
- Rhinovirus Genotypes Circulating in Bulgaria, 2018-2021.Viruses · 2023Article
- Respiratory viruses and postoperative hemodynamics in patients with unrestrictive congenital cardiac communications: a prospective cohort study.European journal of medical research · 2023Article
- The dilemma of improving rational antibiotic use in pediatric community-acquired pneumonia.Frontiers in pediatrics · 2023Review
- Epidemiology and surveillance implications of community-acquired pneumonia in children.Clinical and experimental pediatrics · 2022Article
- Rhinovirus Infection and Virus-Induced Asthma.Viruses · 2022Review
- Viral Infection and Airway Epithelial Immunity in Asthma.International journal of molecular sciences · 2022Review
- Article
67 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human rhinoviruses (HRVs) are well-recognised causes of common colds and associated upper respiratory tract complications such as sinusitis and otitis media. This article reviews information linking HRV infection to illness in the lower respiratory tract. HRVs are capable of efficient replication in vitro at temperatures present in the tracheobronchial tree and have been shown to cause productive infection, elaboration of cytokines and chemokines, and up-regulation of cell surface markers in human bronchial epithelial cells. In situ hybridisation studies have proven that HRV infection occurs in the tracheobronchial tree following experimental infection. Clinical studies report that HRV infection is the second most frequently recognised agent associated with pneumonia and bronchiolitis in infants and young children and commonly causes exacerbations of pre-existing airways disease in those with asthma, chronic obstructive pulmonary disease or cystic fibrosis. HRV infection is associated with one-third to one-half of asthma exacerbations depending on age and is linked to asthma hospitalisations in both adults and children. Limited information implicates HRV infection as a cause of severe lower respiratory tract illness in older adults and in highly immunocompromised hosts, particularly bone marrow transplant recipients. More information is needed about the pathogenesis of HRV infection with regard to lower respiratory tract complications in these diverse patient groups. Given the large unmet medical need associated with HRV infections, safe and effective antiviral agents are needed for both prevention and treatment of these infections.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.