ArticlePflugers Archiv : European journal of physiology2004
SGK1 increases Na,K-ATP cell-surface expression and function in Xenopus laevis oocytes.
Article in Pflugers Archiv : European journal of physiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 76 citations in OpenAlex.
- Canagliflozin Inhibits Electrogenic Na+ Transport in Mouse Cortical Collecting Duct Cells.Function (Oxford, England) · 2025Article
- Association between Decreased SGK1 and Increased Intestinal α-Synuclein in an MPTP Mouse Model of Parkinson's Disease.International journal of molecular sciences · 2023Article
- Coordinated Control of ENaC and Na+,K+-ATPase in Renal Collecting Duct.Journal of the American Society of Nephrology : JASN · 2016Review
- Serum and Glucocorticoid Regulated Kinase 1 in Sodium Homeostasis.International journal of molecular sciences · 2016Review
- Dietary potassium and the renal control of salt balance and blood pressure.Pflugers Archiv : European journal of physiology · 2015Review
- Non-genomic effect of glucocorticoids on cardiovascular system.Pflugers Archiv : European journal of physiology · 2012Review
- Serum- and glucocorticoid-inducible kinase 1 in the regulation of renal and extrarenal potassium transport.Clinical and experimental nephrology · 2012Review
- Epithelial sodium channel regulation by cell surface-associated serum- and glucocorticoid-regulated kinase 1.The Journal of biological chemistry · 2011Article
- SGK1-dependent stimulation of intestinal SGLT1 activity by vitamin D.Pflugers Archiv : European journal of physiology · 2011Article
- Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway.Journal of the American Society of Nephrology : JASN · 2011Article
- Morpholino gene knockdown in adult Fundulus heteroclitus: role of SGK1 in seawater acclimation.PloS one · 2011Article
- Role of epithelial sodium channels and their regulators in hypertension.The Journal of biological chemistry · 2010Review
- Stimulation of electrogenic intestinal dipeptide transport by the glucocorticoid dexamethasone.Pflugers Archiv : European journal of physiology · 2009Article
- Orphan transporter SLC6A18 is renal neutral amino acid transporter B0AT3.The Journal of biological chemistry · 2009Article
- SGK1-sensitive renal tubular glucose reabsorption in diabetes.American journal of physiology. Renal physiology · 2009Article
- SGK1 dependence of insulin induced hypokalemia.Pflugers Archiv : European journal of physiology · 2009Article
- Aldosterone regulation of intestinal Na absorption involves SGK-mediated changes in NHE3 and Na+ pump activity.American journal of physiology. Gastrointestinal and liver physiology · 2008Article
- Crystal structure of the kinase domain of serum and glucocorticoid-regulated kinase 1 in complex with AMP PNP.Protein science : a publication of the Protein Society · 2007Article
- Role of the serum and glucocorticoid inducible kinase SGK1 in glucocorticoid stimulation of gastric acid secretion.Pflugers Archiv : European journal of physiology · 2007Article
- PI3-kinase-dependent electrogenic intestinal transport of glucose and amino acids.Pflugers Archiv : European journal of physiology · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Na(+)-retaining hormone aldosterone increases the cell-surface expression of the luminal epithelial sodium channel (ENaC) and the basolateral Na(+) pump (Na,K-ATPase) in aldosterone-sensitive distal nephron cells in a coordinated fashion. To address the question of whether aldosterone-induced serum and glucocorticoid-regulated kinase-1 (SGK1) might be involved in mediating this regulation of Na,K-ATPase subcellular localization, similar to that of the epithelial Na(+) channel (ENaC), we co-expressed the Na,K-ATPase (rat alpha 1- and Xenopus laevis beta 1-subunits) and Xenopus SGK1 in Xenopus oocytes. Measurements of the Na(+) pump current showed that wild-type SGK1 increases the function of exogenous Na,K-ATPase at the surface of Xenopus oocytes. This appeared to be secondary to an increase in Na,K-ATPase cell-surface expression as visualized by Western blotting of surface-biotinylated proteins. In contrast, the functional surface expression of two other exogenous transporters, the heterodimeric amino acid transporter LAT1-4F2hc and the Na(+)/phosphate cotransporter NaPi-IIa, was not increased by SGK1 co-expression. The total pool of exogenous Na,K-ATPase was increased by the co-expression of SGK1, and similarly also by ENaC co-expression. This latter effect depended on the [Na(+)] of the buffer and was not additive to that of SGK1. When the total Na,K-ATPase was increased by ENaC co-expression, SGK1 still increased Na,K-ATPase cell-surface expression. These observations in Xenopus oocytes suggest the possibility that SGK1 induction and/or activation could participate in the coordinated regulation of Na,K-ATPase and ENaC cell-surface expression in the aldosterone-sensitive distal nephron.
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