ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Spatial and temporal properties of visual responses in the thalamus of the developing ferret.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Premature vision drives aberrant development of response properties in primary visual cortex.eLife · 2025Article
- Premature vision drives aberrant development of response properties in primary visual cortex.bioRxiv : the preprint server for biology · 2025Article
- Self-organization of modular activity in immature cortical networks.Nature communications · 2024Article
- Development, organization and plasticity of auditory circuits: Lessons from a cherished colleague.The European journal of neuroscience · 2019Review
- Article
- Organization of the dorsal lateral geniculate nucleus in the mouse.Visual neuroscience · 2017Review
- Refinement and Pattern Formation in Neural Circuits by the Interaction of Traveling Waves with Spike-Timing Dependent Plasticity.PLoS computational biology · 2015Article
- Emerging feed-forward inhibition allows the robust formation of direction selectivity in the developing ferret visual cortex.Journal of neurophysiology · 2014Article
- Development of cortical orientation selectivity in the absence of visual experience with contour.Journal of neurophysiology · 2011Article
- Activity-dependent disruption of intersublaminar spaces and ABAKAN expression does not impact functional on and off organization in the ferret retinogeniculate system.Neural development · 2011Article
- The developmental remodeling of eye-specific afferents in the ferret dorsal lateral geniculate nucleus.Anatomical record (Hoboken, N.J. : 2007) · 2010Article
- Establishment of a scaffold for orientation maps in primary visual cortex of higher mammals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Spatiotemporal patterning of neural activity is thought to influence the development of connections in the visual pathway. This patterning can arise spontaneously or through sensory experience. Here, we use a combination of natural and simple stimuli to investigate which elements of the visual environment modulate the earliest responses in the primary visual pathway of developing ferrets. Recordings were made during the first 2 weeks of visual responsiveness, which, in the ferret, overlaps with the period that the eyelids have not yet opened. Even when the eyelids are closed, both thalamic and cortical activity was found to be temporally modulated under conditions of natural visual stimulation. The modulations correlated with temporal changes in stimulus contrast but also reflected spatial structure in the visual scene. Simple stimuli were used to show that early responses to naturalistic stimuli are influenced by the localization and structure of through-the-eyelid receptive fields. The early visual responses were also characterized by substantial variability in the ability of the cells to detect stimuli of different duration and different intensity, in a temporally precise manner. These temporal and spatial properties should constrain how plasticity mechanisms interpret naturally patterned activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.