ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2004
Transient electrical coupling delays the onset of chemical neurotransmission at developing synapses.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- Imaging Synaptic Density: The Next Holy Grail of Neuroscience?Frontiers in neuroscience · 2022Review
- Regulatory Roles of Metabotropic Glutamate Receptors on Synaptic Communication Mediated by Gap Junctions.Neuroscience · 2021Review
- Gap Junction Channels of Innexins and Connexins: Relations and Computational Perspectives.International journal of molecular sciences · 2019Review
- Electrical synapses and the development of inhibitory circuits in the thalamus.The Journal of physiology · 2016Article
- In vitro studies of neuronal networks and synaptic plasticity in invertebrates and in mammals using multielectrode arrays.Neural plasticity · 2015Review
- Neuronal somata and extrasomal compartments play distinct roles during synapse formation between Lymnaea neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Electrical synapses and their functional interactions with chemical synapses.Nature reviews. Neuroscience · 2014Review
- Abundance of gap junctions at glutamatergic mixed synapses in adult Mosquitofish spinal cord neurons.Frontiers in neural circuits · 2014Article
- Regulation and restoration of motoneuronal synaptic transmission during neuromuscular regeneration in the pulmonate snail Helisoma trivolvis.The Biological bulletin · 2011Article
- A male poecillid's sexually dimorphic body plan, behavior, and nervous system.Integrative and comparative biology · 2010Article
- Gap junction expression is required for normal chemical synapse formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Serotonin regulates electrical coupling via modulation of extrajunctional conductance: H-current.Brain research · 2010Article
- Experience-dependent maturation of the glomerular microcircuit.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Removal of GABA within adult modulatory systems alters electrical coupling and allows expression of an embryonic-like network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Transient electrical coupling regulates formation of neuronal networks.Brain research · 2007Article
- Molecular characterization and embryonic expression of innexins in the leech Hirudo medicinalis.Development genes and evolution · 2006Article
- Embryonic electrical connections appear to pre-figure a behavioral circuit in the leech CNS.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2006Article
- Flipping the switch from electrical to chemical communication.Nature neuroscience · 2005Article
- Agrin mediates a rapid switch from electrical coupling to chemical neurotransmission during synaptogenesis.The Journal of cell biology · 2005Article
- Dye-coupling visualizes networks of large-field motion-sensitive neurons in the fly.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2005Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
The formation and subsequent elimination of electrical coupling between neurons has been demonstrated in many developing vertebrate and invertebrate nervous systems. The relationship between the disappearance of electrical synaptic connectivity and the appearance of chemical neurotransmission is not well understood. We report here that identified motoneurons from the snail Helisoma formed transient electrical and chemical connections during regeneration both in vivo and in vitro. Electrical connections that formed in vivo were strongest by day 2 and no longer detectable by day 7. During elimination of this electrical connection, an inhibitory chemical connection from 110 onto 19 formed. This sequence of synaptic development was recapitulated in cell culture with a similar time course. The relationship between the appearance of transient electrical coupling and its possible effects on the subsequent chemical synaptogenesis were examined by reducing transient intercellular coupling. Trophic factor-deprived medium resulted in a 66% reduction in coupling coefficient. In these conditions, the unidirectional chemical connection formed readily; in contrast, chemical synaptogenesis was delayed in cell pairs exposed to trophic factors where transient electrical coupling was strong. Dye coupling and synaptic vesicle cycling studies supported electrophysiological results. Exposure to cholinergic antagonists, curare and hexamethonium bromide, which block chemical neurotransmission in these synapses, resulted in prolonged maintenance of the electrical connection. These studies demonstrated an inverse relationship between chemical and electrical connectivity at early stages of synaptic development and suggest a dynamic interaction between these forms of neuronal communication as adult neural networks are constructed or regenerated.
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