ArticleProceedings of the National Academy of Sciences of the United States of America2004
Germinal center-associated nuclear protein contributes to affinity maturation of B cell antigen receptor in T cell-dependent responses.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- Measurement of the absolute mass concentration of antigen-specific serum IgG via quantitative Western blotting.Analytical biochemistry · 2026Article
- Development of a single-chain variable antibody fragment against a conserved region of the SARS-CoV-2 spike protein.Scientific reports · 2024Article
- Identification of biallelic mutations inFrontiers in genetics · 2024Article
- Testicular teratomagenesis from primordial germ cells with overexpression of germinal center-associated nuclear protein.Cancer science · 2023Article
- Article
- Recessive Charcot-Marie-Tooth and multiple sclerosis associated with a variant inBrain communications · 2019Article
- Humanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem.Advances in immunology · 2017Review
- GANP protein encoded on human chromosome 21/mouse chromosome 10 is associated with resistance to mammary tumor development.Cancer science · 2016Article
- Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.Advances in immunology · 2014Review
- The role of activation-induced deaminase in antibody diversification and genomic instability.Immunologic research · 2013Review
- GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy.Nature communications · 2013Article
- Combinatorial mechanisms regulating AID-dependent DNA deamination: interacting proteins and post-translational modifications.Seminars in immunology · 2012Review
- MCM3AP is transcribed from a promoter within an intron of the overlapping gene for GANP.Journal of molecular biology · 2011Article
- GANP-mediated recruitment of activation-induced cytidine deaminase to cell nuclei and to immunoglobulin variable region DNA.The Journal of biological chemistry · 2010Article
- mRNA export from mammalian cell nuclei is dependent on GANP.Current biology : CB · 2010Article
- Decreased expression of germinal center-associated nuclear protein is involved in chromosomal instability in malignant gliomas.Cancer science · 2009Article
- Molecular characterization of hybridoma subclones spontaneously switching at high frequencies in vitro.Journal of immunological methods · 2009Article
- Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis.The Journal of experimental medicine · 2005Article
- GANP enhances the efficiency of mRNA nuclear export in mammalian cells.Nucleus (Austin, Tex.)Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acquired immunity depends on proliferation and differentiation of antigen (Ag)-specific B cells in germinal centers (GCs) of lymphoid follicles in response to T cell-dependent Ags. Here, we studied the function of GC-associated nuclear protein that is selectively up-regulated in GC-B cells. B cell-specific ganp-deficient mice were compromised in affinity maturation of hapten-specific antibodies against T cell-dependent Ags with retarded development of GCs. B cell numbers and development, serum Ig levels, mitogen-induced B cell proliferation in vitro, and responses to T cell-independent Ag were nearly normal; however, the mutant B cells showed a decrease in anti-CD40-induced proliferation and an increased susceptibility to B cell apoptosis in vitro and in vivo. B cell-specific ganp-deficient mice showed a decreased frequency of variable-region somatic mutations, especially of the high-affinity type (W(33) --> L) in the V(H)186.2 region against nitrophenyl-chicken gamma globulin, whereas the class switching was normal. We conclude that GC-associated nuclear protein is necessary for generation or maintenance of B cells with high-affinity B cell Ag receptors during the maturation in GCs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.