ArticleProceedings of the National Academy of Sciences of the United States of America2004
The HcrVf2 gene from a wild apple confers scab resistance to a transgenic cultivated variety.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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Who cites it
72 citing papers in PubMed, 263 citations in OpenAlex.
- Fine-mapping, candidate gene identification, and marker development for the apple scab resistance gene Rvi2.Journal of experimental botany · 2026Article
- Pear scab resistance gene Rvn1 from Ussurian pear is located in a cluster of receptor-like protein ethylene-inducing Xylanase (EIX) genes.BMC plant biology · 2025Article
- Rvi6-mediated defense mechanisms against apple scab.BMC plant biology · 2025Article
- Enhanced scab resistance in apple conferred by Rvi6 and polyploidy is linked with distinct shifts in the phenolics profile.Scientific reports · 2025Article
- Pan-genome analysis reveals the evolution and diversity of Malus.Nature genetics · 2025Article
- All Roads Lead to Rome: Pathways to Engineering Disease Resistance in Plants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- The Hansen's baccata #2 gene Rvi12_Cd5 confers scab resistance to the susceptible apple cultivar "Gala Galaxy".The Plant journal : for cell and molecular biology · 2025Article
- Cotton RLP6 Interacts With NDR1/HIN6 to Enhance Verticillium Wilt Resistance via Altering ROS and SA.Molecular plant pathology · 2025Article
- Mini review: Apple improvement, traditional approaches, biotechnology options, and regulatory considerations.Frontiers in bioengineering and biotechnology · 2025Review
- Article
- Comprehensive Genome-Wide Analysis of the Receptor-like Protein Gene Family and Functional Analysis ofPlants (Basel, Switzerland) · 2024Article
- Phenotyping, genetics, and "-omics" approaches to unravel and introgress enhanced resistance against apple scab (Horticulture research · 2024Article
- Transcriptome analysis under pecan scab infection reveals the molecular mechanisms of the defense response in pecans.PloS one · 2024Article
- Broad-spectrum resistance gene RPW8.1 balances immunity and growth via feedback regulation of WRKYs.Plant biotechnology journal · 2024Article
- Chromosome-level phased genome assembly of "Antonovka" identified candidate apple scab-resistance genes highly homologous to HcrVf2 and HcrVf1 on linkage group 1.G3 (Bethesda, Md.) · 2023Article
- High-qualityFrontiers in plant science · 2023Article
- Comparative transcriptomics unravels new genes imparting scab resistance in apple (Malus x domestica Borkh.).Functional & integrative genomics · 2022Article
- Article
- Identification of receptor-like proteins induced byFrontiers in plant science · 2022Article
- Article
12 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Vf gene from the wild species Malus floribunda 821 is the most studied apple scab resistance gene. Several molecular markers mapping around this gene were the starting point for a positional cloning project. The analysis of the bacterial artificial chromosome clones spanning the Vf region led to the identification of a cluster of genes homologous to the Cladosporium fulvum resistance gene family of tomato. One of these genes, HcrVf2 (homologue of the C. fulvum resistance genes of the Vf region), was used to transform the susceptible apple cultivar Gala. Four independent transformed lines resistant to apple scab were produced, proving that HcrVf2 is sufficient to confer scab resistance to a susceptible cultivar. The results show that direct gene transfer between cross-compatible species can be viable when, as in apple, the use of backcrosses to introduce resistance genes from wild species cannot exactly reconstitute the heterozygous genotype of clonally propagated cultivars.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.