Evidence map›Paper›PMID 14715796›Full record

ArticleJournal of clinical microbiology2004

Strengths and limitations of commercial tests for hepatitis C virus RNA quantification.

Chihiro Morishima, Minjun Chung, Ka Wing Ng, Donald J Brambilla, David R Gretch

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Chihiro MorishimaDepartment of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA.
Minjun Chung
Ka Wing Ng
Donald J Brambilla
David R Gretch
New England Research Institutes · USUniversity of Washington · US

Funding

HEPATITIS C CLINICAL TRIAL-DATA COORDINATING CENTER-267092328N01DK092328 · NIDDK · NEW ENGLAND RESEARCH INSTITUTES, INC. · 1999 to 2004
$1.5M
HEPATITIS C CLINICAL TRIAL- VIROLOGY LABORATORYN01DK092318 · NIDDK · UNIVERSITY OF WASHINGTON · PI GREYCH, DAVID · 1999 to 2000
$317k
NIDDK NIH HHS N01-DK-9-2318NIDDK NIH HHS N01-DK-9-2328
6 · The paper itself

Abstract

The sensitivity of the Roche COBAS Monitor v.2.0 test was slightly better than that of the Bayer bDNA 3.0 test, but the Monitor test underquantified specimens by 2.5- to 10.6-fold even at relatively low hepatitis C virus RNA concentrations. Dilution prior to assay minimally decreased the reproducibility of the Monitor assay, leading to the recommendation for all specimens to be diluted 1:100 prior to testing by this assay.

Indexed as

Reagent Kits, DiagnosticHepacivirusReproducibility of ResultsRNA, ViralSensitivity and SpecificityReagent Kits, DiagnosticRNA, Viral

Identifiers

PMID14715796
PMCPMC321650
OpenAlexW2131221081

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.