ArticleJournal of clinical microbiology2004
Sensitivity of respiratory virus culture when screening with R-mix fresh cells.
Article in Journal of clinical microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
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- Advances in Diagnostic Techniques for Influenza Virus Infection: A Comprehensive Review.Tropical medicine and infectious disease · 2025Review
- Viral Coinfections.Viruses · 2022Review
- Biographical Feature: Karen C. Carroll, M.D.Journal of clinical microbiology · 2021Article
- Virological and Immunological Outcomes of Coinfections.Clinical microbiology reviews · 2018Review
- Influenza.Nature reviews. Disease primers · 2018Review
- Benefits and drawbacks of molecular techniques for diagnosis of viral respiratory infections. Experience with two multiplex PCR assays.Journal of medical virology · 2016Article
- Surveillance for emerging respiratory viruses.The Lancet. Infectious diseases · 2014Review
- Duplex molecular assay intended for point-of-care diagnosis of influenza A/B virus infection.Journal of clinical microbiology · 2013Article
- Article
- Laboratory detection of respiratory viruses by automated techniques.The open virology journal · 2012Article
- [Children with cancer and respiratory viral infection: epidemiology, diagnosis and treatment options].Enfermedades infecciosas y microbiologia clinica · 2011Review
- Performance of diagnostic tests to detect respiratory viruses in older adults.Diagnostic microbiology and infectious disease · 2010Article
- Developments in tissue culture detection of respiratory viruses.Clinics in laboratory medicine · 2009Review
- Comparison of viral isolation and multiplex real-time reverse transcription-PCR for confirmation of respiratory syncytial virus and influenza virus detection by antigen immunoassays.Journal of clinical microbiology · 2009Article
- Real-time PCR compared to Binax NOW and cytospin-immunofluorescence for detection of influenza in hospitalized patients.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2008Article
- Detection of respiratory viruses by molecular methods.Clinical microbiology reviews · 2008Review
- Respiratory virus panels for global surveillance of emerging infectious diseases.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2007Review
- [Respiratory viruses: old and new. Review of diagnostic methods].Enfermedades infecciosas y microbiologia clinica · 2007Article
- Respiratory virus infections.Paediatric respiratory reviews · 2007Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Use of R-Mix Fresh Cells has been shown to be a rapid and sensitive method for the detection and identification of respiratory viruses. We prospectively evaluated the impact of incorporation of R-Mix shell vials on the sensitivity and time to detection of seven respiratory viruses recovered in a comprehensive culture during the course of an entire respiratory season in a high-volume clinical laboratory. In this study, R-Mix shell vials were used as part of the culture of 3803 respiratory specimens. A total of 428 respiratory viruses were recovered. Staining of R-Mix vials after overnight incubation allowed initial detection of 274 of 279 influenza viruses, 33 of 38 parainfluenza viruses, 35 of 51 adenoviruses, and 52 of 60 respiratory syncytial viruses (RSVs). The time to reporting of all positive cultures after in-lab specimen receipt was 2.9 days on average and those initially detected in R-Mix cells were reported in 2.3 days on average. A combination of direct fluorescent-antibody (DFA) staining and virus culture was performed on a subset of 711 respiratory specimens. Of 152 viruses identified, 57 were observed only with DFA testing (55 RSV and 2 influenza A viruses) and 31 were recovered only in cell culture. After overnight incubation, R-Mix cells detected 87.1% of respiratory viruses not observed by DFA testing and 96.9% of viruses positive by both methods. The sensitivities of DFA testing and R-Mix cells for identification of influenza viruses were 70.5% and 96.7%, respectively. The R-Mix method detected influenza virus in 18 samples that were negative by DFA testing.
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