ArticleJournal of clinical microbiology2004
Molecular epidemiology of the iron utilization genes of enteroaggregative Escherichia coli.
Article in Journal of clinical microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 58 citations in OpenAlex.
- Antimicrobial resistance and genomic characteristics of bovine Escherichia coli from five northern provinces of China.BMC genomics · 2026Article
- EHEC O111:H8 strain and norovirus GII.4 Sydney [P16] causing an outbreak in a daycare center, Brazil, 2019.BMC microbiology · 2021Article
- Article
- A large self-transmissible resistance plasmid from Nigeria contains genes that ameliorate a carrying cost.Scientific reports · 2019Article
- Typical and Atypical EnteroaggregativeFrontiers in microbiology · 2019Article
- High prevalence of diarrheagenic Escherichia coli carrying toxin-encoding genes isolated from children and adults in southeastern Brazil.BMC infectious diseases · 2017Article
- Prevalence and virulence gene profiling of enteroaggregative Escherichia coli in malnourished and nourished Brazilian children.Diagnostic microbiology and infectious disease · 2017Article
- Riboregulators: Fine-Tuning Virulence in Shigella.Frontiers in cellular and infection microbiology · 2016Review
- Haemolytic-uraemic syndrome with bacteraemia caused by a new hybrid Escherichia coli pathotype.New microbes and new infections · 2014Article
- Iron, copper, zinc, and manganese transport and regulation in pathogenic Enterobacteria: correlations between strains, site of infection and the relative importance of the different metal transport systems for virulence.Frontiers in cellular and infection microbiology · 2013Review
- RNA-mediated thermoregulation of iron-acquisition genes in Shigella dysenteriae and pathogenic Escherichia coli.PloS one · 2013Article
- In vivo bioluminescence imaging of Escherichia coli O104:H4 and role of aerobactin during colonization of a mouse model of infection.BMC microbiology · 2012Article
- The heat-resistant agglutinin family includes a novel adhesin from enteroaggregative Escherichia coli strain 60A.Journal of bacteriology · 2011Article
- Molecular risk assessment and epidemiological typing of Shiga toxin-producing Escherichia coli by using a novel PCR binary typing system.Applied and environmental microbiology · 2011Article
- Subpathotypes of Avian Pathogenic Escherichia coli (APEC) Exist as Defined by their Syndromes and Virulence Traits.The open microbiology journal · 2011Article
- Multi-locus sequence typing of enteroaggregative Escherichia coli isolates from Nigerian children uncovers multiple lineages.PloS one · 2010Article
- A pathoadaptive deletion in an enteroaggregative Escherichia coli outbreak strain enhances virulence in a Caenorhabditis elegans model.Infection and immunity · 2010Article
- A second large plasmid encodes conjugative transfer and antimicrobial resistance in O119:H2 and some typical O111 enteropathogenic Escherichia coli strains.Journal of bacteriology · 2007Article
- Enteroaggregative Escherichia coli related to uropathogenic clonal group A.Emerging infectious diseases · 2007Article
- Error-prone DNA repair system in enteroaggregative Escherichia coli identified by subtractive hybridization.Journal of bacteriology · 2007Article
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Enteroaggregative Escherichia coli (EAEC) strains are etiologic agents of acute and persistent diarrhea. In this study, the results of phenotypic assays suggested that EAEC strains possess specialized iron acquisition systems. Genes required for the synthesis (iucA) or transport (fepC) of siderophores, and genes encoding siderophore (fyuA, ireA, and iroN) or heme transport (chu) receptors or hemoglobin proteases (pic and hbp), were sought in EAEC strains which have been characterized with respect to known virulence genes and phylogeny. The chuA, iucA, fyuA, fepC, and pic genes were detected in 33, 76.2, 85.7, 33, and 61.9% of these EAEC strains, respectively, and the other genes were absent. The majority of EAEC strains possessed genes encoding multiple iron transport systems, and there was no phylogenetic correlation in the distribution of the majority of these loci, as is typical for EAEC. The notable exceptions were chuA and fepC (which is associated with the prrA-modA-fepC pathogenicity island); these genes were restricted to the EAEC2 and DAEC2 phylogenetic groups, which could represent pathogenic subsets. When collections of EAEC strains isolated during case-control studies in Nigeria and Brazil were examined, no association of the presence of either chuA or iucA alone with diarrhea was seen, but both genes together were present in significantly more strains from cases than from controls in the Nigerian collection (P < 0.05). It is possible that the presence of both genes marks at least some virulent strains. The data also demonstrate geographical variation in the association of iron utilization genes with disease in EAEC.
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