ArticleClinical and diagnostic laboratory immunology2004
Systemic and mucosal responses to oral administration of excretory and secretory antigens from Giardia intestinalis.
Article in Clinical and diagnostic laboratory immunology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 66 citations in OpenAlex.
- The pathogenic responses elicited during exposure of human intestinal cell line with Giardia duodenalis excretory-secretory products and the potential attributed endocytosis mechanism.Medical microbiology and immunology · 2024Article
- Respiratory allergy symptoms and cytokine profiles in the presence of anti-Ascaris antibody in Giardia lamblia-infected children.Parasitology research · 2023Article
- Characterization of the Giardia intestinalis secretome during interaction with human intestinal epithelial cells: The impact on host cells.PLoS neglected tropical diseases · 2017Article
- The Intersection of Immune Responses, Microbiota, and Pathogenesis in Giardiasis.Trends in parasitology · 2017Review
- Hypereosinophilia in a Young Patient: Occam's Razor or Hickam's Dictum?Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2016Article
- Disruptions of Host Immunity and Inflammation by Giardia Duodenalis: Potential Consequences for Co-Infections in the Gastro-Intestinal Tract.Pathogens (Basel, Switzerland) · 2015Review
- Giardia duodenalis-induced alterations of commensal bacteria kill Caenorhabditis elegans: a new model to study microbial-microbial interactions in the gut.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- Antibody and cytokine responses to Giardia excretory/secretory proteins in Giardia intestinalis-infected BALB/c mice.Parasitology research · 2014Article
- Breast-feeding protects infantile diarrhea caused by intestinal protozoan infections.The Korean journal of parasitology · 2013Article
- Persistent G. lamblia impairs growth in a murine malnutrition model.The Journal of clinical investigation · 2013Article
- Effect of urbanisation on the relationship between total serum IgE and asthma.The European respiratory journal · 2013Article
- Host-parasite interaction: parasite-derived and -induced proteases that degrade human extracellular matrix.Journal of parasitology research · 2012Article
- Comparison of protein-free defined media, and effect of L-cysteine and ascorbic acid supplementation on viability of axenic Entamoeba histolytica.Parasitology research · 2011Article
- Giardia duodenalis: the double-edged sword of immune responses in giardiasis.Experimental parasitology · 2010Review
- Protease activity in extracellular products secreted in vitro by trophozoites of Giardia duodenalis.Parasitology research · 2008Article
- Release of metabolic enzymes by Giardia in response to interaction with intestinal epithelial cells.Molecular and biochemical parasitology · 2008Article
- Infection of dogs by experimental inoculation with human isolates of Giardia duodenalis: clinical and laboratory manifestations.Veterinary parasitology · 2007Article
- Excreted/secreted glycoproteins of G. intestinalis play an essential role in the antibody response.Parasitology research · 2007Article
- Review
- Severe weight loss in lambs infected with Giardia duodenalis assemblage B.Veterinary parasitology · 2006Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Giardia, a flagellated protozoan that infects the upper small intestine of its vertebrate host, is the most common parasitic protist responsible for diarrhea worldwide. Molecules released by the parasite, particularly excretory and secretory antigens, seemed to be associated with pathogenesis as well as with the expression of Giardia virulence. In the present work, we examined the effect of oral administration of Giardia intestinalis excretory and secretory antigens on systemic and local antibody response as well as on mucosal injuries in BALB/c mice. Significant titers of serum-specific immunoglobulin G1 (IgG1) and specific IgG2a were observed. Systemic and mucosal specific IgA antibodies were also recorded. A transient production of serum-specific IgE antibody and high total IgE levels were also detected, suggesting the presence in excretory and secretory proteins of factors promoting a specific IgE response. The sera of excretory and secretory antigen-treated mice recognized proteins of 50 and 58 kDa as well as electrophoretic bands of 15, 63, and 72 kDa that could support a proteinase activity. The in vitro exposure of G. intestinalis trophozoites to heat-inactivated sera from mice orally inoculated with excretory and secretory antigens induced a decrease of growth, revealing a complement-independent inhibitory activity of specific serum antibodies. Furthermore, histological evaluation performed on the small and large intestines revealed moderate to acute histological changes comparable to those observed in natural or experimental Giardia infection characterized by eosinophilic infiltration, hypercellularity, and enterocytic desquamation. The present results suggested that Giardia excretory and secretory antigens stimulate a preferential Th2 response, which is probably involved in the intestinal alterations associated with giardiasis.
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