ArticleAnnals of clinical microbiology and antimicrobials2004
Comparison in a rat thigh abscess model of imipenem, meropenem and cefoperazone-sulbactam against Acinetobacter baumannii strains in terms of bactericidal efficacy and resistance selection.
Article in Annals of clinical microbiology and antimicrobials, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Large-scale identification of pathogen essential genes during coinfection with sympatric and allopatric microbes.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Bacterial fight-and-flight responses enhance virulence in a polymicrobial infection.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Metabolite cross-feeding enhances virulence in a model polymicrobial infection.PLoS pathogens · 2011Article
- Acinetobacter baumannii: emergence of a successful pathogen.Clinical microbiology reviews · 2008Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe compared imipenem, meropenem and cefoperazone-sulbactam against hospital originated A. baumannii strains in terms of bactericidal efficacy and selection of resistant mutants during treatment in a rat thigh abscess model.
methodsA total of 18 strains were inoculated in 54 animals (one strain for three animals). Randomly selected 10 among these 18 strains were inoculated in another 10 rats as the control group. Imipenem, meropenem and cefoperazone-sulbactam were the antibiotics compared. After four days of treatment, Wistar albino rats (200 to 250 g) were sacrificed and the abscess materials were processed for mean colony counts and for the presence of resistant mutants.
resultsThe mean CFUs per gram (mean +/- (std. deviation) [x10(4)]) of the abscess were: 9,14 (25,24), 2,11 (3,78), 1,20 (1,70) in the imipenem (n = 17), meropenem (n = 18) and cefoperazone-sulbactam (n = 17) groups, respectively. The differences were not significant. On the other hand, no resistant mutant was detected in abscess materials.
conclusionThis study indicated; first, cefoperazone-sulbactam is comparable to carbapenems in bactericidal efficacy in this particular abscess model and second, emergence of resistance due to spontaneous mutations is not at least a frequent phenomenon among A. baumannii.
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