ArticleJournal of molecular medicine (Berlin, Germany)2004
Retinoic acid receptor alpha and retinoid X receptor specific agonists reduce renal injury in established chronic glomerulonephritis of the rat.
Article in Journal of molecular medicine (Berlin, Germany), 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 47 citations in OpenAlex.
- Vitamin A and retinoid signaling in the kidneys.Pharmacology & therapeutics · 2023Review
- Effects of ATRA on diabetic rats with renal ischemia-reperfusion injury.Acta cirurgica brasileira · 2020Article
- ATRA attenuate proteinuria via downregulation of TRPC6 in glomerulosclerosis rats induced by adriamycin.Renal failure · 2018Article
- Estrogen Receptor α Signaling Exacerbates Immune-Mediated Nephropathies through Alteration of Metabolic Activity.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Inhibition of HDAC enhances STAT acetylation, blocks NF-κB, and suppresses the renal inflammation and fibrosis inAmerican journal of physiology. Renal physiology · 2017Article
- Association of Retinoid X Receptor Alpha Gene Polymorphism with Clinical Course of Chronic Glomerulonephritis.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- All-Trans Retinoic Acid Has a Potential Therapeutic Role for Diabetic Nephropathy.Yonsei medical journal · 2015Article
- All-trans retinoic acid and sodium butyrate enhance natriuretic peptide receptor a gene transcription: role of histone modification.Molecular pharmacology · 2014Article
- An in vitro model for the pro-fibrotic effects of retinoids: mechanisms of action.British journal of pharmacology · 2013Article
- Integrated expression profiles of mRNA and miRNA in polarized primary murine microglia.PloS one · 2013Article
- The controversial role of retinoic acid in fibrotic diseases: analysis of involved signaling pathways.International journal of molecular sciences · 2012Review
- Association of retinoic acid receptors with extracellular matrix accumulation in rats with renal interstitial fibrosis disease.International journal of molecular sciences · 2012Article
- Effect of all-trans retinoic acid on renal expressions of matrix metalloproteinase-2, matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in rats with glomerulosclerosis.Pediatric nephrology (Berlin, Germany) · 2009Article
- Chronic low-dose isotretinoin treatment limits renal damage in subtotally nephrectomized rats.Journal of molecular medicine (Berlin, Germany) · 2009Article
- Therapeutics in renal disease: the road ahead for antiproliferative targets.Nephron. Experimental nephrology · 2006Article
- Hepatocyte growth factor receptor signaling mediates the anti-fibrotic action of 9-cis-retinoic acid in glomerular mesangial cells.The American journal of pathology · 2005Article
- Would a vitamin help, doctor?Journal of molecular medicine (Berlin, Germany) · 2004Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retinoids, derivatives of vitamin A, inhibit mesangial cell proliferation, glomerular inflammation, and extracellular matrix deposition in acute anti-Thy1.1 glomerulonephritis (Thy-GN) of the rat. We examined a model, chronic mesangioproliferative Thy-GN (MoAb 1-22-3), which is more akin to human disease. Treatment started on day 23 when Thy-GN had already been established. Nonnephritic control and Thy-GN rats were treated orally for 67 days with vehicle or with two doses of either the retinoic acid receptor alpha-specific agonist AGN 195183 (RARalpha agonist) or the retinoid X receptor specific agonist AGN 194204 (RXR agonist). Doses of either the RARalpha or the RXR agonist significantly reduced albuminuria and normalized blood pressure during the course of treatment. The glomerulosclerosis index, glomerular cell and interstitial cell counts, and area of the interstitial space were significantly lower in nephritic rats treated with the RARalpha agonist or RXR agonist than with vehicle. The RARalpha and RXR agonist significantly reduced the infiltration of the glomerulus by macrophages. The increase in glomerular TGFbeta1 and prepro-ET(1) gene expression in vehicle-treated nephritic rats was significantly attenuated by RARalpha or RXR agonists. Glomerular expression of RXRalpha and RARalpha receptor mRNA was significantly greater in vehicle-treated nephritic rats than in nonnephritic controls. Treatment with RARalpha or RXR agonists tended to normalize retinoid-receptor gene expression. Our data indicate that both RARalpha agonists and RXR agonists reduce renal damage in rats with established chronic glomerulonephritis. Receptor-specific retinoids may provide a novel therapeutic approach for the treatment of chronic glomerulonephritis.
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