ReviewGene therapy2004
Gene therapy progress and prospects: noninvasive imaging of gene therapy in living subjects.
Review in Gene therapy, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- PET reporter systems for the brain.Trends in neurosciences · 2023Review
- Use of Molecular Imaging in Clinical Drug Development: a Systematic Review.Nuclear medicine and molecular imaging · 2019Article
- Drug Discovery by Molecular Imaging and Monitoring Therapy Response in Lymphoma.International journal of molecular sciences · 2017Review
- Radioiodinated Capsids Facilitate In Vivo Non-Invasive Tracking of Adeno-Associated Gene Transfer Vectors.Scientific reports · 2017Article
- Review
- In vivo imaging of transplanted stem cells in the central nervous system.Current opinion in genetics & development · 2014Review
- Utilization of neural stem cell-derived models to study anesthesia-related toxicity and preventative approaches.Molecular neurobiology · 2013Review
- From gene engineering to gene modulation and manipulation: can we prevent or detect gene doping in sports?Sports medicine (Auckland, N.Z.) · 2013Review
- C-5 hydroxyethyl and hydroxypropyl acyclonucleosides as substrates for thymidine kinase of herpes simplex virus type 1 (HSV-1 TK): syntheses and biological evaluation.Molecules (Basel, Switzerland) · 2013Article
- Advanced pre-clinical research approaches and models to studying pediatric anesthetic neurotoxicity.Frontiers in neurology · 2012Article
- Suicidal gene therapy in an NF-κB-controlled tumor environment as monitored by a secreted blood reporter.Gene therapy · 2011Article
- Imaging gene expression in live cells and tissues.Cold Spring Harbor protocols · 2011Article
- In vivo fluorescence imaging is well-suited for the monitoring of adenovirus directed transgene expression in living organisms.Molecular imaging and biology · 2010Article
- Molecular imaging of biological gene delivery vehicles for targeted cancer therapy: beyond viral vectors.Nuclear medicine and molecular imaging · 2010Article
- Magnetic resonance imaging of cells in experimental disease models.Progress in nuclear magnetic resonance spectroscopy · 2009Article
- PET imaging of thymidine kinase gene expression in the liver of non-human primates following systemic delivery of an adenoviral vector.Gene therapy · 2009Article
- A new acycloguanosine-specific supermutant of herpes simplex virus type 1 thymidine kinase suitable for PET imaging and suicide gene therapy for potential use in patients treated with pyrimidine-based cytotoxic drugs.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2008Article
- Noninvasive molecular neuroimaging using reporter genes: part II, experimental, current, and future applications.AJNR. American journal of neuroradiology · 2008Review
- Imaging chemically modified adenovirus for targeting tumors expressing integrin alphavbeta3 in living mice with mutant herpes simplex virus type 1 thymidine kinase PET reporter gene.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2006Article
- Gene therapy imaging in patients for oncological applications.European journal of nuclear medicine and molecular imaging · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent progress in the development of noninvasive imaging technologies should allow molecular imaging to play a major role in the field of gene therapy. These tools have recently been validated in gene therapy models for continuous quantitative monitoring of the location(s), magnitude, and time variation of gene delivery and/or expression. This article reviews the use of radionuclide, magnetic resonance, and optical imaging technologies, as they have been used in imaging gene delivery and gene expression for gene therapy applications. The studies published to date lend support that noninvasive imaging tools will help to accelerate preclinical model validation, as well as allow for clinical monitoring of human gene therapy.
Indexed as
Identifiers
14712295What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.