ArticleOncogene2004
Proteasome-dependent dispersal of PML nuclear bodies in response to alkylating DNA damage.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Recruitment of TRIM33 to cell-context specific PML nuclear bodies regulates nodal signaling in mESCs.The EMBO journal · 2023Article
- Mitochondrial DNA: cellular genotoxic stress sentinel.Trends in biochemical sciences · 2021Review
- Article
- PML-like subnuclear bodies, containing XRCC1, juxtaposed to DNA replication-based single-strand breaks.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Article
- Assembly of Epstein-Barr Virus Capsid in Promyelocytic Leukemia Nuclear Bodies.Journal of virology · 2015Article
- Ubiquitin-specific Protease 11 (USP11) Deubiquitinates Hybrid Small Ubiquitin-like Modifier (SUMO)-Ubiquitin Chains to Counteract RING Finger Protein 4 (RNF4).The Journal of biological chemistry · 2015Article
- DNA mismatch repair proteins are required for efficient herpes simplex virus 1 replication.Journal of virology · 2011Article
- Nuclear organization in genome stability: SUMO connections.Cell research · 2011Review
- Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screen.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- A manually curated network of the PML nuclear body interactome reveals an important role for PML-NBs in SUMOylation dynamics.International journal of biological sciences · 2010Review
- Telomeric DNA mediates de novo PML body formation.Molecular biology of the cell · 2009Article
- The ubiquitin-proteasome system in cancer, a major player in DNA repair. Part 2: transcriptional regulation.Journal of cellular and molecular medicine · 2009Review
- ASCIZ regulates lesion-specific Rad51 focus formation and apoptosis after methylating DNA damage.The EMBO journal · 2005Article
- ND10 components relocate to sites associated with herpes simplex virus type 1 nucleoprotein complexes during virus infection.Journal of virology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Promyelocytic leukemia protein (PML) nuclear bodies (NBs) are present in variable number in most human cell types and have been linked to various cellular functions, including roles as depots for DNA repair proteins. Here, we show that treatment of human cells with DNA methylating agents leads to redistribution of PML from NBs to a diffuse nuclear localization. Biochemically, this correlates with a specific reduction of PML levels in the nuclear matrix fraction without affecting total PML levels. Similar results were obtained for the other major PML NB component, the Sp100 protein, indicating that DNA methylating agents lead to a general disassembly of PML NBs. Similar to the dispersal of PML NBs in response to some viral infections, PML redistribution after DNA damage was inhibited by the proteasome inhibitor MG132. We propose that the regulated dispersal of PML NBs may facilitate the enhanced release of DNA repair proteins from NB depots in order to respond adequately to extensive DNA damage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.