ArticleOncogene2004
Mapping and characterization of the minimal internal ribosome entry segment in the human c-myc mRNA 5' untranslated region.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Principles for targeting RNA with drug-like small molecules.Nature reviews. Drug discovery · 2018Review
- ATF2 translation is induced under chemotherapeutic drug-mediated cellular stress via an IRES-dependent mechanism in human hepatic cancer Bel7402 cells.Oncology letters · 2016Article
- Small molecule inhibitors of IRES-mediated translation.Cancer biology & therapy · 2015Article
- Translation from a DMD exon 5 IRES results in a functional dystrophin isoform that attenuates dystrophinopathy in humans and mice.Nature medicine · 2014Article
- The current status of vertebrate cellular mRNA IRESs.Cold Spring Harbor perspectives in biology · 2013Review
- Cryptic transcripts from a ubiquitous plasmid origin of replication confound tests for cis-regulatory function.Nucleic acids research · 2012Article
- Translational modulation of proteins expressed from bicistronic vectors.Molecular imaging · 2009Article
- Cap-independent translation of human SP-A 5'-UTR variants: a double-loop structure and cis-element contribution.American journal of physiology. Lung cellular and molecular physiology · 2009Article
- mRNA translation regulation by the Gly-Ala repeat of Epstein-Barr virus nuclear antigen 1.Journal of virology · 2009Article
- Activation of cap-independent translation by variant eukaryotic initiation factor 4G in vivo.RNA (New York, N.Y.) · 2008Article
- A search for structurally similar cellular internal ribosome entry sites.Nucleic acids research · 2007Article
- Searching for IRES.RNA (New York, N.Y.) · 2006Review
- A positive feedback vector for identification of nucleotide sequences that enhance translation.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human c-myc proto-oncogene is transcribed from four alternative promoters generating transcripts with 5' untranslated regions of various lengths. These transcripts encode two proteins, c-Myc1 and c-Myc2, from two initiation codons, CUG and AUG, respectively. We and others have previously demonstrated that the region of c-myc transcripts between nucleotides (nt) -363 and -94 upstream from the CUG start codon contained an internal ribosome entry site leading to the cap-independent translation of c-myc open reading frames (ORFs). Here, we mapped a 50-nt sequence (-143 -94), which is sufficient to promote internal translation initiation of c-myc ORFs. Interestingly, this 50-nt element can be further dissected into two segments of 14 nt, each capable of activating internal translation initiation. We also demonstrate that this 50-nt element acts as the ribosome landing site from which the preinitiation ribosomal complex scans the mRNA until the CUG or AUG start codons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.