ArticleOncogene2004
DBCCR1 mediates death in cultured bladder tumor cells.
Article in Oncogene, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Repurposing a pore: highly conserved perforin-like proteins with alternative mechanisms.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Identification of DBCCR1 as a suppressor in the development of lung cancer that is associated with increased DNA methyltransferase 1.Oncotarget · 2017Article
- The Membrane Attack Complex/Perforin Superfamily.Journal of molecular microbiology and biotechnology · 2017Article
- Relationships between Circulating Urea Concentrations and Endometrial Function in Postpartum Dairy Cows.Animals : an open access journal from MDPI · 2015Article
- Cloning and characterization of the porcine DBC1 gene encoding deleted in bladder cancer.Molecular biology reports · 2015Article
- Mapping of the chromosomal amplification 1p21-22 in bladder cancer.BMC research notes · 2014Article
- Decreased DBC1 Expression Is Associated With Poor Prognosis in Patients With Non-Muscle-Invasive Bladder Cancer.Korean journal of urology · 2013Article
- Methylomic analysis identifies frequent DNA methylation of zinc finger protein 582 (ZNF582) in cervical neoplasms.PloS one · 2012Article
- Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.Annals of human genetics · 2010Article
- Epigenetic remodeling during arsenical-induced malignant transformation.Carcinogenesis · 2008Article
- Superficial bladder cancer: an update on etiology, molecular development, classification, and natural history.Reviews in urology · 2008Article
- DBC1 re-expression alters the expression of multiple components of the plasminogen pathway.Oncogene · 2006Article
- Methylation in the promoter regions of WT1, NKX6-1 and DBC1 genes in cervical cancer tissues of Uygur women in Xinjiang.Genetics and molecular biologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Chromosome 9, which is often partially or fully reduced to homozygosity in bladder cancer cells, harbors several tumor suppressor loci including deleted in bladder cancer chromosome region 1 (DBCCR1) at 9q32-33. To study DBCCR1 function, stable cell lines, inducible for DBCCR1 expression by tetracycline, were made, but the DBCCR1 protein was not expressed at detectable levels. To understand the fate of DBCCR1-expressing cells, human bladder tumor cells were transiently transfected with an expression vector containing DBCCR1 fused to enhanced green fluorescent protein (EGFP). Initially, DBCCR1-EGFP-expressing cells demonstrated diffuse cytoplasmic green fluorescence with nuclear exclusion patterns. After time, the intensity level of green fluorescence increased and a granular distribution of protein became visible in the cells. At this point, cells rounded up and detached from the tissue culture dish. Cells transfected with a control vector, containing only EGFP, and partial DBCCR1-EGFP fusion constructs did not demonstrate this behavior. DBCCR1-mediated cell death in cultured tumor cells was independent of caspase-3 activation and did not result in detectable DNA strand breaks by TUNEL staining that are hallmarks of the classical apoptotic pathway.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.