ArticleProceedings of the National Academy of Sciences of the United States of America2004
Assessing fitness costs for transgenic Aedes aegypti expressing the GFP marker and transposase genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it, 134 citations in OpenAlex.
- A meta-analysis of the factors influencing development rate variation in Aedes aegypti (Diptera: Culicidae).BMC ecology · 2014Pooled it
- Exploring the dynamics of symbiont Enterobacter aerogenes expressing Cry1Ac for potential biocontrol of Helicoverpa armigera.World journal of microbiology & biotechnology · 2026Article
- An OpIE2-DsRed marker disrupts female blood-feeding and shortens lifespan in the malaria vector Anopheles gambiae.Genetics · 2026Article
- Direct and transgenerational effects of tetracyclines on the microbiome, transcriptome, and male mating behavior of the sheep blowfly Lucilia cuprina.G3 (Bethesda, Md.) · 2025Article
- Quantifying Fitness Costs in Transgenic Aedes aegypti Mosquitoes.Journal of visualized experiments : JoVE · 2023Article
- Driving down malaria transmission with engineered gene drives.Frontiers in genetics · 2022Review
- The impact of transgenesis on mosquito fitness: A review.Frontiers in insect science · 2022Review
- Sex, age, and parental harmonic convergence behavior affect the immune performance of Aedes aegypti offspring.Communications biology · 2021Article
- Assessment of Developmental and Reproductive Fitness of Dengue-Resistant TransgenicBioMed research international · 2021Article
- Mating Competitiveness of Transgenic Aedes aegypti (Diptera: Culicidae) Males Against Wild-Type Males Reared Under Simulated Field Conditions.Journal of medical entomology · 2020Article
- Copy-number variation introduced by long transgenes compromises mouse male fertility independently of pachytene checkpoints.Chromosoma · 2020Article
- Effects of larval diets and temperature regimes on life history traits, energy reserves and temperature tolerance of male Aedes aegypti (Diptera: Culicidae): optimizing rearing techniques for the sterile insect programmes.Parasites & vectors · 2019Article
- Aseptic Rearing and Infection with Gut Bacteria Improve the Fitness of Transgenic Diamondback Moth,Insects · 2019Article
- Site-specific transgenesis of the Drosophila melanogaster Y-chromosome using CRISPR/Cas9.Insect molecular biology · 2019Article
- Molecular tools to create new strains for mosquito sexing and vector control.Parasites & vectors · 2018Review
- Comparative phylogeography ofEcology and evolution · 2018Article
- Article
- Synthetic miRNAs induce dual arboviral-resistance phenotypes in the vector mosquitoCommunications biology · 2018Article
- Maintaining Quality of Candidate Strains of Transgenic Mosquitoes for Studies in Containment Facilities in Disease Endemic Countries.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2018Article
- Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
The development of transgenic mosquitoes that are refractory to the transmission of human diseases such as malaria, dengue, and yellow fever has received much interest due to the ability to transform a number of vector mosquito species with transposable elements. Transgenic strains of mosquitoes have been generated with molecular techniques that exhibit a reduced capacity to transmit pathogens. These advancements have led to questions regarding the fitness of transgenic mosquitoes and the ability of transformed mosquitoes to compete and effectively spread beneficial genes through nontransformed field populations, the core requirement of a genetically based control strategy aimed at reducing the spread of mosquito-borne human disease. Here we examine the impact of transgenesis on the fitness of Aedes aegypti, a mosquito that transmits yellow fever. Mosquitoes were altered with two types of transgene, the enhanced GFP gene and two transposase genes from the Hermes and MOS1 transposable elements. We examined the effects of these elements on the survivorship, longevity, fecundity, sex ratio, and sterility of transformed mosquitoes and compared results to the nontransformed laboratory strain. We show that demographic parameters are significantly diminished in transgenic mosquitoes relative to the untransformed laboratory strain. Reduced fitness in transgenic mosquitoes has important implications for the development and utilization of this technology for control programs based on manipulative molecular modification.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.