ArticleApplied and environmental microbiology2004
Differential stress-induced regulation of two quinone reductases in the brown rot basidiomycete Gloeophyllum trabeum.
Article in Applied and environmental microbiology, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 63 citations in OpenAlex.
- Unlocking the distinctive enzymatic functions of the early plant biomass deconstructive genes in a brown rot fungus by cell-free protein expression.Applied and environmental microbiology · 2024Article
- ThemSphere · 2023Article
- Capturing an Early Gene Induction Event during Wood Decay by the Brown Rot FungusApplied and environmental microbiology · 2022Article
- Phenolic signals for prehaustorium formation inFrontiers in plant science · 2022Article
- Multi-omics analysis provides insights into lignocellulosic biomass degradation by Laetiporus sulphureus ATCC 52600.Biotechnology for biofuels · 2021Article
- Differential Roles of a Family of Flavodoxin-Like Proteins That Promote Resistance to Quinone-Mediated Oxidative Stress in Candida albicans.Infection and immunity · 2021Article
- Plasma Membrane MCC/Eisosome Domains Promote Stress Resistance in Fungi.Microbiology and molecular biology reviews : MMBR · 2020Review
- Transcriptome analysis of the brown rot fungus Gloeophyllum trabeum during lignocellulose degradation.PloS one · 2020Article
- Transcriptome and Secretome Analyses of the Wood Decay Fungus Wolfiporia cocos Support Alternative Mechanisms of Lignocellulose Conversion.Applied and environmental microbiology · 2016Article
- Flavodoxin-Like Proteins Protect Candida albicans from Oxidative Stress and Promote Virulence.PLoS pathogens · 2015Article
- Tenebrionid secretions and a fungal benzoquinone oxidoreductase form competing components of an arms race between a host and pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Novel traits of Trichoderma predicted through the analysis of its secretome.FEMS microbiology letters · 2012Review
- Proteomic and functional analysis of the cellulase system expressed by Postia placenta during brown rot of solid wood.Applied and environmental microbiology · 2011Article
- Comparative transcriptome and secretome analysis of wood decay fungi Postia placenta and Phanerochaete chrysosporium.Applied and environmental microbiology · 2010Article
- Induction of extracellular hydroxyl radical production by white-rot fungi through quinone redox cycling.Applied and environmental microbiology · 2009Article
- Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Saline-dependent regulation of manganese peroxidase genes in the hypersaline-tolerant white rot fungus Phlebia sp. strain MG-60.Applied and environmental microbiology · 2008Article
- Crystal structure of the NADH:quinone oxidoreductase WrbA from Escherichia coli.Journal of bacteriology · 2007Article
- Characteristics of Gloeophyllum trabeum alcohol oxidase, an extracellular source of H2O2 in brown rot decay of wood.Applied and environmental microbiology · 2007Article
- Crystallization and preliminary diffraction analysis of Escherichia coli WrbA in complex with its cofactor flavin mononucleotide.Acta crystallographica. Section F, Structural biology and crystallization communications · 2007Article
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Authors and funding
3 authors at 2 institutions in 1 country.
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Abstract
Quinone reductases (QRDs) have two important functions in the basidiomycete Gloeophyllum trabeum, which causes brown rot of wood. First, a QRD is required to generate biodegradative hydroxyl radicals via redox cycling between two G. trabeum extracellular metabolites, 2,5-dimethoxyhydroquinone (2,5-DMHQ) and 2,5-dimethoxy-1,4-benzoquinone (2,5-DMBQ). Second, because 2,5-DMBQ is cytotoxic and 2,5-DMHQ is not, a QRD is needed to maintain the intracellular pool of these metabolites in the reduced form. Given their importance in G. trabeum metabolism, QRDs could prove useful targets for new wood preservatives. We have identified two G. trabeum genes, each existing in two closely related, perhaps allelic variants, that encode QRDs in the flavodoxin family. Past work with QRD1 and heterologous expression of QRD2 in this study confirmed that both genes encode NADH-dependent, flavin-containing QRDs. Real-time reverse transcription PCR analyses of liquid- and wood-grown cultures showed that qrd1 expression was maximal during secondary metabolism, coincided with the production of 2,5-DMBQ, and was moderately up-regulated by chemical stressors such as quinones. By contrast, qrd2 expression was maximal during fungal growth when 2,5-DMBQ levels were low, yet was markedly up-regulated by chemical stress or heat shock. The total QRD activity in lysates of G. trabeum mycelium was significantly enhanced by induction beforehand with a cytotoxic quinone. The promoter of qrd2 contains likely antioxidant, xenobiotic, and heat shock elements, absent in qrd1, that probably explain the greater response of qrd2 transcription to stress. We conclude from these results that QRD1 is the enzyme G. trabeum routinely uses to detoxify quinones during incipient wood decay and that it could also drive the biodegradative quinone redox cycle. However, QRD2 assumes a more important role when the mycelium is stressed.
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