Evidence map›Paper›PMID 14711538›Full record

ArticleFertility and sterility2004

Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome.

Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group

20 registry-linked trialsAbstract readConsensus Statement
PubMed Publisher
In one paragraph

Article in Fertility and sterility, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 20 registered trials, which are not on this map. Cited by 2,161 papers, 23 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2,161citing papers in PubMed, 23 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07759674 phase4completedstarted 2023, after this paper: background citation

Effects of Routine Metformin Therapy on Insulin Resistance, Iron Metabolism, Erythropoietin, Lipid Profile, and Hematological Parameters in Jordanian Women With Polycystic Ovary Syndrome: A Prospective Longitudinal Interventional Study

Ran2023Enrolled25Registered outcomes7Posted comparisons0ConditionsInsulin Resistance Syndrome, Polycystic Ovary Syndrome (PCOS) WomenArmsMetformin
PMID 25333031PMID 37589624other papers from this trial
Open the trial in the graph
NCT00593294 phase4completednot on this mapstarted 2006, after this paper: background citation

Comparison of Oral Contraceptive Versus Physical Exercise Effects on Cardiovascular and Metabolic Risk Factors in PCOS Women

TypeinterventionalSponsorFederico II UniversityRan2006 to 2007Enrolled150ConditionsPolycystic Ovary SyndromeArmsPhysical exercise, OC - Drospirenone plus Ethynylestradiol, Vitamin, polyvitamins tablets
NCT00784615 unknown statusnot on this mapstarted 2007, after this paper: background citation

Descriptive, Transversal Study of Evaluation of Cardiovascular Risks Factors and Prevalence of Metabolic Syndrome in the Different Phenotypes of Women With Polycystic Ovary Syndrome

TypeobservationalSponsorUniversidad Nacional de CórdobaRan2007Enrolled80ConditionsPolycystic Ovary SyndromeArmsBlood samples, transvaginal ultrasound
NCT02385396 phase2completednot on this map

Evaluation Concerning the Influence of Myo-inositol Therapy on the Dynamics of Embryo Development in Patients Suffering From PCOS Undergoing ICSI Treatment

TypeinterventionalSponsorMedical University of LublinEnrolled217ConditionsPolycystic Ovary Syndrome, InfertilityArmsInofolic: myo-inositol and folic acid
NCT02523898 phase2terminatednot on this mapstarted 2015, after this paper: background citation

Is the Co-administration of Metformine and CC as Compared to Placebo and CC Superior to Induce Ovulation in PCOS Patients With a Confirmed insulin-resistant-a Double Blind Randomized Clinical Trial

TypeinterventionalSponsorSemnan University of Medical SciencesRan2015 to 2022Enrolled388ConditionsPolycystic Ovary Syndrome, HyperandrogenismArmsmetformine, placebo, clomiphene citrate
NCT02715336 phase4unknown statusnot on this mapstarted 2015, after this paper: background citation

A Randomized Controlled Trial of Pre-retrieval Triggering Methods in in Vitro Fertilization Patients Classified as Low, Normal or High Responder

TypeinterventionalSponsorCreate Fertility CenterRan2015 to 2021Enrolled666ConditionsIVF Cycle, Ovarian Stimulation, Egg Retrieval, PregnancyArmsOvulation induction with hCG and Lupron (GnRH agonist)
NCT02865187 nacompletednot on this mapstarted 2017, after this paper: background citation

Evaluation of Vitamin D With and Without Hormonal Contraception on Sexual Function in Women With Polycystic Ovary Syndrome

TypeinterventionalSponsorWright State UniversityRan2017 to 2020Enrolled47ConditionsFemale Sexual Dysfunction, Polycystic Ovary SyndromeArmsVitamin D, Hormonal contraception
NCT03440359 phase2 / phase3completednot on this mapstarted 2012, after this paper: background citation

"Supplementation of the Luteal Phase With Vaginal Progesterone (Crinone 8%) in Women With Polycystic Ovary Syndrome Undergoing Ovulation Induction With Letrozole: A Prospective and Randomized Controlled Trial

TypeinterventionalSponsorEastern Virginia Medical SchoolRan2012 to 2017Enrolled52ConditionsPolycystic Ovary SyndromeArmsProgesterone Vaginal Gel 8%, Letrozole Oral Tablet, pelvic ultrasound, Ovidrel 250 MCG Per 0.5 ML Prefilled Syringe, Intrauterine insemination or timed intercourse
NCT03608813 completednot on this mapstarted 2016, after this paper: background citation

Effects of a Combined Treatment With Myo-inositol, D-chiro-inositol and Glucomannan in Women With PCOS

TypeobservationalSponsorUniversity of SalernoRan2016 to 2017Enrolled120ConditionsPCOSArmsSerum Metabolomics profiling
NCT04006171 nacompletednot on this mapstarted 2019, after this paper: background citation

C Type Natriuretic Peptide and Polycystic Ovary Syndrome

TypeinterventionalSponsorNear East University, TurkeyRan2019 to 2020Enrolled90ConditionsPolycystic Ovary Syndrome, c Type Natriuretic Peptide, Menstrual Irregularity, HyperandrogenismArmsC type natriuretic peptide
NCT04117750 nacompletednot on this mapstarted 2017, after this paper: background citation

Impact of Vitamin D Supplementation on the Cardiometabolic Status and Androgen Profile in Women With Polycystic Ovary Syndrome: Placebo-Controlled Clinical Trial

TypeinterventionalSponsorZagazig UniversityRan2017 to 2018Enrolled145ConditionsEvaluations, Diagnostic Self, Treatment AdherenceArmscholecalciferol (vit D3)
NCT04727671 phase4completednot on this mapstarted 2019, after this paper: background citation

Effect of GnRH Agonist (Long Protocol) vs GnRH Antagonist (Flexible Protocol) on IVF/ICSI Outcomes in Polycystic Ovary Syndrome Patients.

TypeinterventionalSponsorDamascus UniversityRan2019 to 2021Enrolled50ConditionsIn Vitro Fertilization, Intracytoplasmic Sperm Injection, Infertility, Polycystic Ovary SyndromeArmsTriptorelin acetate, Cetrorelix, recombinant-FSH or recombinant-FSH + human Menopausal Gonadotropin, Human Chorionic Gonadotropin (hCG)
NCT04727684 phase4completednot on this mapstarted 2020, after this paper: background citation

Effect of GnRH Agonist (Long Protocol) vs GnRH Antagonist (Flexible Protocol) on Oocyte Morphology in Polycystic Ovary Syndrome Patients During IVF/ICSI

TypeinterventionalSponsorDamascus UniversityRan2020 to 2022Enrolled50ConditionsIn Vitro Fertilization, Infertility, Intracytoplasmic Sperm Injection, Polycystic Ovary SyndromeArmsTriptorelin acetate, Cetrorelix, recombinant-FSH or recombinant-FSH + human Menopausal Gonadotropin, Human Chorionic Gonadotropin (hCG)
NCT04805853 unknown statusnot on this mapstarted 2020, after this paper: background citation

Myocardial Pathological Changes in Patients of Type 2 Diabetes With or Without PCOS Using Cardiac Magnetic Resonance

Typeobservational_patient_registrySponsorRenJi HospitalRan2020 to 2022Enrolled561ConditionsType2 Diabetes, Polycystic Ovary Syndrome
NCT05298657 unknown statusnot on this mapstarted 2022, after this paper: background citation

The Angiotensin-Melatonin Axis in Poor and Hyper Responders for IVF Treatment

Typeobservational_patient_registrySponsorFatima College of Health SciencesRan2022 to 2024Enrolled200ConditionsPoor Response to Ovulation Induction, PCOS, Endometriosis, Infertility, Female
NCT05402800 unknown statusnot on this mapstarted 2022, after this paper: background citation

Sexual Dysfunction in Infertile Women With PCOS Undergoing Fertility Treatment

TypeobservationalSponsorCairo UniversityRan2022 to 2022Enrolled186ConditionsSexual Dysfunction, PCOSArmsFSFI questionnaire
NCT05438355 completednot on this mapstarted 2021, after this paper: background citation

The Effect of Polycystic Ovary Syndrome on the Morphokinetics or Abnormalities on Early Embryonic Development: a Time Lapse Study

TypeobservationalSponsorShangHai Ji Ai Genetics & IVF InstituteRan2021 to 2021Enrolled153ConditionsPCOS
NCT05473273 recruitingnot on this mapstarted 2023, after this paper: background citation

Descriptive Analysis of Serum Immunological Markers During an Euploid Frozen Embryo Transfer in a Natural Cycle (NC).

TypeobservationalSponsorART Fertility Clinics LLCRan2023 to 2026Enrolled40ConditionsInfertility, FemaleArmsEndometrin 100Mg Vaginal Insert, Estradiol Valerate
NCT05638529 phase4unknown statusnot on this mapstarted 2019, after this paper: background citation

Dual Versus Single Trigger in IVF Patients at High Risk of Ovarian Hyper Stimulation Syndrome: a Randomized, Double-blinded, Controlled Trial.

TypeinterventionalSponsorMount Sinai Hospital, CanadaRan2019 to 2023Enrolled80ConditionsOvarian Hyperstimulation Syndrome, Infertility, FemaleArmsPregnyl (1,500) IU, 1.5 mL of normal saline
NCT06256289 phase4unknown statusnot on this mapstarted 2024, after this paper: background citation

Efficacy of Canagliflozin Versus Metformin in Women With Polycystic Ovary Syndrome Combined With Non-Alcoholic Fatty Liver Disease: A Single-center, Open-labeled Prospective Randomized Controlled

TypeinterventionalSponsorPing Li,MDRan2024 to 2025Enrolled50ConditionsPolycystic Ovary Syndrome, Non-Alcoholic Fatty Liver DiseaseArmsCanagliflozin 100mg Tab, Metformin Hydrochloride
3 · Its place in the literature

Who cites it

2,161 citing papers in PubMed, 23 syntheses or guidelines pooled it.

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2,101 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the 1990 National Institutes of Health-sponsored conference on polycystic ovary syndrome (PCOS), it has become appreciated that the syndrome encompasses a broader spectrum of signs and symptoms of ovarian dysfunction than those defined by the original diagnostic criteria. The 2003 Rotterdam consensus workshop concluded that PCOS is a syndrome of ovarian dysfunction along with the cardinal features hyperandrogenism and polycystic ovary (PCO) morphology. PCOS remains a syndrome, and as such no single diagnostic criterion (such as hyperandrogenism or PCO) is sufficient for clinical diagnosis. Its clinical manifestations may include menstrual irregularities, signs of androgen excess, and obesity. Insulin resistance and elevated serum LH levels are also common features in PCOS. PCOS is associated with an increased risk of type 2 diabetes and cardiovascular events.

Indexed as

Clinical Trials as TopicFemaleHumansHyperandrogenismInsulin ResistanceLuteinizing HormonePolycystic Ovary SyndromeRisk FactorsLuteinizing Hormone

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 14 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.