ArticleDocumenta ophthalmologica. Advances in ophthalmology2003
Changes in the electroretinogram resulting from discontinuation of vigabatrin in children.
Article in Documenta ophthalmologica. Advances in ophthalmology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02299115 (Prednisolone vs. Vigabatrin in the First-line Treatment of Infantile Spasms), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prednisolone vs. Vigabatrin in the First-line Treatment of Infantile Spasms
Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Effects of fixed cutoff filtering on dark- and light-adapted ERG components and the application of variable cutoff filter.Documenta ophthalmologica. Advances in ophthalmology · 2022Article
- Trends and Costs Associated With the Diagnosis and Treatment of Infantile Spasms: A 10-Year Multicenter Retrospective Review.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022Article
- What can visual electrophysiology tell about possible visual-field defects in paediatric patients.Eye (London, England) · 2021Review
- Reliability of Handheld Optical Coherence Tomography in Children Younger Than Three Years of Age Undergoing Vigabatrin Treatment for Childhood Epilepsy.Translational vision science & technology · 2020Article
- Retinal defect in children with infantile spasms of varying etiologies: An observational study.Neurology · 2020Observational
- Vigabatrin-Induced Retinal Functional Alterations and Second-Order Neuron Plasticity in C57BL/6J Mice.Investigative ophthalmology & visual science · 2020Article
- Vigabatrin retinal toxicity in children with infantile spasms: An observational cohort study.Neurology · 2014Observational
- Electroretinographic (ERG) responses in pediatric patients using vigabatrin.Documenta ophthalmologica. Advances in ophthalmology · 2012Article
- Epilepsy: Vigabatrin treatment and visual field loss.Nature reviews. Neurology · 2011Article
- The safety and tolerability of newer antiepileptic drugs in children and adolescents.CNS drugs · 2010Review
- Article
- Reduced grating acuity associated with retinal toxicity in children with infantile spasms on vigabatrin therapy.Investigative ophthalmology & visual science · 2009Article
- Dose-related changes in retinal function and PKC-alpha expression in rabbits on vigabatrin medication. Effect of vigabatrin in the rabbit eye.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2009Article
- Full-field ERG and visual fields in patients 5 years after discontinuing vigabatrin therapy.Documenta ophthalmologica. Advances in ophthalmology · 2008Article
- Vigabatrin.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2007Review
- Retinal function in rabbits does not improve 4-5 months after terminating treatment with vigabatrin.Documenta ophthalmologica. Advances in ophthalmology · 2006Article
- Reduced visual function associated with infantile spasms in children on vigabatrin therapy.Investigative ophthalmology & visual science · 2005Article
- Characteristic retinal atrophy with secondary "inverse" optic atrophy identifies vigabatrin toxicity in children.Ophthalmology · 2004Article
- Longitudinal changes in photopic OPs occurring with vigabatrin treatment.Documenta ophthalmologica. Advances in ophthalmology · 2003Article
- Effects of medications on the human electroretinogram: A comprehensive review.Survey of ophthalmologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Electroretinograms (ERGs) have been recorded longitudinally in children before and during treatment with the antiepileptic drug vigabatrin for the past 3.5 years. Vigabatrin induced changes in ERG responses occur in children; the most dramatic changes occur in the oscillatory potentials. The purpose of this study was to identify changes in ERG responses associated with discontinuation of vigabatrin treatment. If vigabatrin-induced changes reverse after discontinuation of the drug we infer that the original change is not an indicator of toxicity. ERG data were analyzed from 17 children who discontinued vigabatrin therapy. The duration of treatment ranged from 5 to 52 months, the age for the first ERG ranged from 6 to 38 months (median 10 months). ERGs were tested using the standard protocol established by the International Society for Clinical Electrophysiology of Vision, with Burian-Allen bipolar contact-lens electrodes. In addition to standard responses we recorded photopic oscillatory potentials (OPs). During vigabatrin treatment OPs show a greater change than other ERG responses, with the early occurring wavelets from the photopic OPs showing the greatest change. With discontinuation of vigabatrin the amplitude of the early wavelets of the photopic OPs increased dramatically compared with amplitudes while taking the drug (paired t-test, p = 0.000075). The scotopic oscillatory potentials also show some recovery. Although changes in oscillatory potentials may occur with vigabatrin toxicity, a large change likely occurs with a non-toxic pharmacological effect of vigabatrin on GABAergic amacrine cells in the inner plexiform layer. Reduction of OPs in children on vigabatrin may not be related to toxicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.