ArticleDocumenta ophthalmologica. Advances in ophthalmology2003
Longitudinal changes in photopic OPs occurring with vigabatrin treatment.
Article in Documenta ophthalmologica. Advances in ophthalmology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Use of Visual Electrophysiology to Monitor Retinal and Optic Nerve Toxicity.Biomolecules · 2022Review
- Ocular examinations, findings, and toxicity in children taking vigabatrin.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2022Article
- Effects of fixed cutoff filtering on dark- and light-adapted ERG components and the application of variable cutoff filter.Documenta ophthalmologica. Advances in ophthalmology · 2022Article
- Vigabatrin-Induced Retinal Functional Alterations and Second-Order Neuron Plasticity in C57BL/6J Mice.Investigative ophthalmology & visual science · 2020Article
- Vigabatrin can enhance electroretinographic responses in pigmented and albino rats.Documenta ophthalmologica. Advances in ophthalmology · 2015Article
- Vigabatrin retinal toxicity in children with infantile spasms: An observational cohort study.Neurology · 2014Observational
- Electroretinographic (ERG) responses in pediatric patients using vigabatrin.Documenta ophthalmologica. Advances in ophthalmology · 2012Article
- Reduced grating acuity associated with retinal toxicity in children with infantile spasms on vigabatrin therapy.Investigative ophthalmology & visual science · 2009Article
- Vigabatrin.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2007Review
- Characteristic retinal atrophy with secondary "inverse" optic atrophy identifies vigabatrin toxicity in children.Ophthalmology · 2004Article
- Changes in the electroretinogram resulting from discontinuation of vigabatrin in children.Documenta ophthalmologica. Advances in ophthalmology · 2003Article
- Effects of medications on the human electroretinogram: A comprehensive review.Survey of ophthalmologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
purposeVigabatrin (gamma-vinyl-GABA) is an antiepileptic drug successful in the management of infantile spasms. Photopic ERGs were tested in children followed longitudinally before and during vigabatrin treatment.
methodsSubjects were 26 infants (age range 1.5-24 months, median 7.6 months) on vigabatrin treatment who had been tested on multiple visits (two to four visits; mean, three visits). Eighteen of these were assessed initially before starting vigabatrin therapy and eight were assessed within 1 week of initiation of the drug. ERGs were recorded at 6-month intervals. Standard ISCEV protocol with Burian-Allen bipolar contact-lens electrodes (standard flash 2.0 cd.s/m2) was used. Although ISCEV standards were followed, a higher flash intensity (set at 3.6 cd.s/m2) was chosen for single-flash cone assessment to provide a better definition of OPs. Photopic OPs were divided into categories of early OPs and late OP (OP4). Responses were compared with age corrected limits extrapolated from our lab control database.
resultsResults showed differential effects of vigabatrin on the summed early OP amplitudes versus the late OP (OP4) and cone b-wave amplitude. The early OPs showed significant decrease (p = 0.0005, repeated measures analysis of variance) after 6 months and remained decreased for the duration of treatment. There was no significant change seen in the late OP. The cone b-wave amplitude showed initial increase (p = 0.04) after 6 months, followed by a decrease after 18 months; a trend similar to that of the late OP.
conclusionEarly photopic OPs were disrupted more than the late OP, suggesting relative deficit in the ON (depolarizing) retinal pathways.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.