ArticleEMBO reports2004
Cyclin B degradation leads to NuMA release from dynein/dynactin and from spindle poles.
Article in EMBO reports, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 49 citations in OpenAlex.
- The Impact of Centrosome Pathologies on Ovarian Cancer Development and Progression with a Focus on Centrosomes as Therapeutic Target.Advances in experimental medicine and biology · 2024Review
- Cancer Cells Haploinsufficient for ATM Are Sensitized to PARP Inhibitors byInternational journal of molecular sciences · 2022Article
- NuMA regulates mitotic spindle assembly, structural dynamics and function via phase separation.Nature communications · 2021Article
- The Nuclear Mitotic Apparatus (NuMA) Protein: A Key Player for Nuclear Formation, Spindle Assembly, and Spindle Positioning.Frontiers in cell and developmental biology · 2021Review
- A genome-wide enrichment screen identifies NUMA1-loss as a resistance mechanism against mitotic cell-death induced by BMI1 inhibition.PloS one · 2020Article
- Multisite Phosphorylation of NuMA-Related LIN-5 Controls Mitotic Spindle Positioning in C. elegans.PLoS genetics · 2016Article
- KSHV Genome Replication and Maintenance.Frontiers in microbiology · 2016Review
- NuMA phosphorylation by CDK1 couples mitotic progression with cortical dynein function.The EMBO journal · 2013Article
- NuMA is required for the selective induction of p53 target genes.Molecular and cellular biology · 2013Article
- P21-activated kinase 4 (PAK4) is required for metaphase spindle positioning and anchoring.Oncogene · 2013Article
- Kaposi's Sarcoma-Associated Herpesvirus Genome Replication, Partitioning, and Maintenance in Latency.Frontiers in microbiology · 2012Article
- NuMA after 30 years: the matrix revisited.Trends in cell biology · 2010Review
- NuMA is required for proper spindle assembly and chromosome alignment in prometaphase.BMC research notes · 2009Article
- A cell cycle timer for asymmetric spindle positioning.PLoS biology · 2009Article
- Human papillomavirus E7 protein deregulates mitosis via an association with nuclear mitotic apparatus protein 1.Journal of virology · 2009Article
- The mammalian centrosome and its functional significance.Histochemistry and cell biology · 2008Review
- NuMA influences higher order chromatin organization in human mammary epithelium.Molecular biology of the cell · 2007Article
- Rae1 interaction with NuMA is required for bipolar spindle formation.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- NuMA is a major acceptor of poly(ADP-ribosyl)ation by tankyrase 1 in mitosis.The Biochemical journal · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
Abstract
The protein NuMA localizes to mitotic spindle poles where it contributes to the organization of microtubules. In this study, we demonstrate that NuMA loses its stable association with the spindle poles after anaphase onset. Using extracts from Xenopus laevis eggs, we show that NuMA is dephosphorylated in anaphase and released from dynein and dynactin. In the presence of a nondegradable form of cyclin B (Delta90), NuMA remains phosphorylated and associated with dynein and dynactin, and remains localized to stable spindle poles that fail to disassemble at the end of mitosis. Inhibition of NuMA or dynein allows completion of mitosis, despite inducing spindle pole abnormalities. We propose that NuMA functions early in mitosis during the formation of spindle poles, but is released from the spindle after anaphase, to allow spindle disassembly and remodelling of the microtubule network.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.