ArticleJournal of neurocytology2003
Cell type-specific reduction of beta tubulin isotypes synthesized in the developing gerbil organ of Corti.
Article in Journal of neurocytology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 39 citations in OpenAlex.
- MicroRNA Signature and Cellular Characterization of Undifferentiated and Differentiated House Ear Institute-Organ of Corti 1 (HEI-OC1) Cells.Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Regenerated hair cells in the neonatal cochlea are innervated and the majority co-express markers of both inner and outer hair cells.Frontiers in cellular neuroscience · 2022Article
- In focus in HCB.Histochemistry and cell biology · 2020Article
- Spatio-temporal distribution of tubulin-binding cofactors and posttranslational modifications of tubulin in the cochlea of mice.Histochemistry and cell biology · 2020Article
- Expression of trans-membrane serine protease 3 (TMPRSS3) in the human organ of Corti.Cell and tissue research · 2018Article
- Developmental abnormalities in supporting cell phalangeal processes and cytoskeleton in theDisease models & mechanisms · 2018Article
- Full-length cloning, sequence analysis and expression detection of the β-tubulin gene from the Chinese gall aphid (Schlechtendalia chinensis).Scientific reports · 2017Article
- The Histochemistry and Cell Biology omnium-gatherum: the year 2015 in review.Histochemistry and cell biology · 2016Review
- Spatio-temporal dynamics of β-tubulin isotypes during the development of the sensory auditory organ in rat.Histochemistry and cell biology · 2015Article
- AP-1-mediated expression of brain-specific class IVa β-tubulin in P19 embryonal carcinoma cells.The Journal of veterinary medical science · 2014Article
- Generation of Atoh1-rtTA transgenic mice: a tool for inducible gene expression in hair cells of the inner ear.Scientific reports · 2014Article
- Molecular profile of cochlear immunity in the resident cells of the organ of Corti.Journal of neuroinflammation · 2014Article
- Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo.Development (Cambridge, England) · 2014Article
- Marshalin, a microtubule minus-end binding protein, regulates cytoskeletal structure in the organ of Corti.Biology open · 2013Article
- Neural stem cells injected into the sound-damaged cochlea migrate throughout the cochlea and express markers of hair cells, supporting cells, and spiral ganglion cells.Hearing research · 2007Article
- Lateral wall protein content mediates alterations in cochlear outer hair cell mechanics before and after hearing onset.Cell motility and the cytoskeleton · 2007Article
- Basic helix-loop-helix gene Hes6 delineates the sensory hair cell lineage in the inner ear.Developmental dynamics : an official publication of the American Association of Anatomists · 2006Article
- Cells, molecules and morphogenesis: the making of the vertebrate ear.Brain research · 2006Review
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Authors and funding
5 authors at 3 institutions in 1 country.
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Abstract
There are seven isotypic forms of the microtubule protein beta tubulin in mammals, but not all isotypes are synthesized in every cell type. In the adult organ of Corti, each of the five major cell types synthesizes a different subset of isotypes. Inner hair cells synthesize only betaI and betaII tubulin, while outer hair cells make betaI and betaIV tubulin. Only betaII and betaIV tubulin are found in inner and outer pillar cells, while betaI, betaII, and betaIV tubulin are present in Deiters cells, and betaI, betaII and betaIII tubulin are found in organ of Corti dendrites. During post-natal organ of Corti development in the gerbil, microtubules are elaborated in an orderly temporal sequence beginning with hair cells, followed by pillar cells and Deiters cells. Using beta tubulin isotype-specific antibodies, we show that, in the gerbil cochlea, the same three isotypes are present in each cell type at birth, and that a cell type-specific reduction in the isotypes synthesized occurs in hair cells and pillar cells at an unusually late stage in development. No beta tubulin isotypes were detected in mature afferent dendrites, but we show that this is because few microtubules are present in mature dendrites. In addition, we show that primary cilia in inner hair cells, a feature of early development, persist much later than previously reported. The findings represent the first description of developmental cell type-specific reductions in tubulin isotypes in any system.
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