ArticleGenome research2004
A whole-genome mouse BAC microarray with 1-Mb resolution for analysis of DNA copy number changes by array comparative genomic hybridization.
Article in Genome research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 162 citations in OpenAlex.
- Human molecular cytogenetics: From cells to nucleotides.Genetics and molecular biology · 2014Review
- Characterising chromosome rearrangements: recent technical advances in molecular cytogenetics.Heredity · 2012Review
- Numbers of genes in the NBS and RLK families vary by more than four-fold within a plant species and are regulated by multiple factors.Nucleic acids research · 2010Article
- Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers.BMC cancer · 2010Article
- Loss of Rb proteins causes genomic instability in the absence of mitogenic signaling.Genes & development · 2010Article
- Error-prone translesion replication of damaged DNA suppresses skin carcinogenesis by controlling inflammatory hyperplasia.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice.Nature genetics · 2009Article
- Candidate metastasis suppressor genes uncovered by array comparative genomic hybridization in a mouse allograft model of prostate cancer.Molecular cytogenetics · 2009Article
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- Identification of cancer genes using a statistical framework for multiexperiment analysis of nondiscretized array CGH data.Nucleic acids research · 2008Article
- A genome assembly-integrated dog 1 Mb BAC microarray: a cytogenetic resource for canine cancer studies and comparative genomic analysis.Cytogenetic and genome research · 2008Article
- Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Identification of novel amplification gene targets in mouse and human breast cancer at a syntenic cluster mapping to mouse ch8A1 and human ch13q34.Cancer research · 2007Article
- A high utility integrated map of the pig genome.Genome biology · 2007Article
- Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human.The American journal of pathology · 2007Article
- Human and mouse oligonucleotide-based array CGH.Nucleic acids research · 2005Article
- Construction of a 2-Mb resolution BAC microarray for CGH analysis of canine tumors.Genome research · 2005Article
- Comparative genomic hybridization on mouse cDNA microarrays and its application to a murine lymphoma model.Oncogene · 2005Article
- X-ray-induced deletion complexes in embryonic stem cells on mouse chromosome 15.Mammalian genome : official journal of the International Mammalian Genome Society · 2005Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 3 countries.
Funding
Abstract
Microarray-based comparative genomic hybridization (CGH) has become a powerful method for the genome-wide detection of chromosomal imbalances. Although BAC microarrays have been used for mouse CGH studies, the resolving power of these analyses was limited because high-density whole-genome mouse BAC microarrays were not available. We therefore developed a mouse BAC microarray containing 2803 unique BAC clones from mouse genomic libraries at 1-Mb intervals. For the general amplification of BAC clone DNA prior to spotting, we designed a set of three novel degenerate oligonucleotide-primed (DOP) PCR primers that preferentially amplify mouse genomic sequences while minimizing unwanted amplification of contaminating Escherichia coli DNA. The resulting 3K mouse BAC microarrays reproducibly identified DNA copy number alterations in cell lines and primary tumors, such as single-copy deletions, regional amplifications, and aneuploidy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.