ArticleDigestive diseases and sciences2003
Gastric carcinogenesis by duodenal reflux through gut regenerative cell lineage.
Article in Digestive diseases and sciences, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- How to Define the Gastroesophageal Junction.Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2026Review
- The epigenetic modifier lysine methyltransferase 2C is frequently mutated in gastric remnant carcinoma.The journal of pathology. Clinical research · 2023Article
- Article
- Development of Pancreatic Acinar Cell Metaplasia During Gastric Repair in a Rat Duodenal Contents Reflux Model.Digestive diseases and sciences · 2021Article
- Columnar epithelium morphology after esophagectomy: clinical insight into the development of Barrett's esophagus.Esophagus : official journal of the Japan Esophageal Society · 2020Article
- Barretts's carcinogenesis.Pathology international · 2019Article
- Gastric adenocarcinoma at the anastomotic site 50 years after gastrojejunostomy: A case report.Molecular and clinical oncology · 2017Article
- Gastritis cystica profunda in a previously unoperated stomach: a case report.World journal of gastroenterology · 2015Article
- [Barrett's esophagus: analyses from human and experimental animal studies].Der Pathologe · 2013Article
- Barrett's esophagus and animal models.Annals of the New York Academy of Sciences · 2011Article
- Inflammation-related carcinogenesis and prevention in esophageal adenocarcinoma using rat duodenoesophageal reflux models.Cancers · 2011Article
- Bile acids as endogenous etiologic agents in gastrointestinal cancer.World journal of gastroenterology · 2009Article
- Article
- Article
- Adenoma with gastric differentiation (so-called pyloric gland adenoma) in a heterotopic gastric corpus mucosa in the rectum.Virchows Archiv : an international journal of pathology · 2005Article
- Expression of Cdx2 in early GRCL of Barrett's esophagus induced in rats by duodenal reflux.Digestive diseases and sciences · 2005Article
- Frequent loss of RUNX3 gene expression in remnant stomach cancer and adjacent mucosa with special reference to topography.British journal of cancer · 2005Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To elucidate the histogenesis of gastric stump cancer, we performed an operation in rats to make all duodenal contents flow back into the glandular stomach. The subjects were 41 rats, and sequential morphological changes of the duodenogastric stoma and the incidence of stump cancers were studied. Serial sections around the stoma were studied with mucin stains such as paradoxical concanavalin A (Con A), galactose oxidase Schiff (GOS), and high-iron diamine-Alcian blue (HID-AB). An immunohistochemical study on cell proliferation with bromodeoxyuridine (BrdU) was also done. At week 30, pyloric gland type cells positive for Con A first appeared at the base of the intestinal crypts and the fundic glands adjacent to the anastomosis. These glands became large with time, resulting in formation of cystically dilated glands. These gland cells were partially stained with GOS, and then they retained a proliferative activity. These changes seemed to resemble "gastritis cystica profunda" in human remnant stomachs. At 50 and 80 weeks, adenocarcinomas were observed in 4 of 10 rats (40.0%) and in 16 of 21 rats (76.2%), respectively. We have noted that the early change of cystic proliferation of mucous glands resembled the so-called "ulcer associated cell lineage (UACL)" described by others, but our characteristic finding was not only pyloric but also foveolar metaplasia. This pyloric-foveolar metaplasia subsequently led to development of glands with intestinal-type goblet cells, which looked like incomplete intestinal metaplasia. This sequence was different from UACL, and very recently, we proposed a concept of "gut regenerative cell lineage (GRCL); from pyloric-foveolar to with goblet cell metaplasia in regeneration," common to all parts of the gut, and the stump cancer appeared to arise from GRCL.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.