ArticleNucleic acids research2004
The last CTD repeat of the mammalian RNA polymerase II large subunit is important for its stability.
Article in Nucleic acids research, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 69 citations in OpenAlex.
- RNA polymerase II CTD is dispensable for transcription and required for termination in human cells.EMBO reports · 2023Article
- RNA polymerase II condensate formation and association with Cajal and histone locus bodies in living human cells.Genes to cells : devoted to molecular & cellular mechanisms · 2021Article
- Extension of the minimal functional unit of the RNA polymerase II CTD from yeast to mammalian cells.Biology letters · 2019Article
- Casein Kinase II Phosphorylation of Spt6 Enforces Transcriptional Fidelity by Maintaining Spn1-Spt6 Interaction.Cell reports · 2018Article
- The RNA polymerase II CTD "orphan" residues: Emerging insights into the functions of Tyr-1, Thr-4, and Ser-7.Transcription · 2018Review
- Function and control of RNA polymerase II C-terminal domain phosphorylation in vertebrate transcription and RNA processing.Molecular and cellular biology · 2014Article
- Article
- RNA polymerase II C-terminal domain: Tethering transcription to transcript and template.Chemical reviews · 2013Review
- The RNA polymerase II CTD coordinates transcription and RNA processing.Genes & development · 2012Review
- Threonine-4 of mammalian RNA polymerase II CTD is targeted by Polo-like kinase 3 and required for transcriptional elongation.The EMBO journal · 2012Article
- Serine-7 but not serine-5 phosphorylation primes RNA polymerase II CTD for P-TEFb recognition.Nature communications · 2012Article
- TCERG1 regulates alternative splicing of the Bcl-x gene by modulating the rate of RNA polymerase II transcription.Molecular and cellular biology · 2012Article
- Article
- Genetic organization, length conservation, and evolution of RNA polymerase II carboxyl-terminal domain.Molecular biology and evolution · 2010Article
- The non-canonical CTD of RNAP-II is essential for productive RNA synthesis in Trypanosoma brucei.PloS one · 2009Article
- Splicing- and cleavage-independent requirement of RNA polymerase II CTD for mRNA release from the transcription site.The Journal of cell biology · 2007Article
- The C-terminal domain of RNA Pol II helps ensure that editing precedes splicing of the GluR-B transcript.RNA (New York, N.Y.) · 2007Article
- C-terminal motif prediction in eukaryotic proteomes using comparative genomics and statistical over-representation across protein families.BMC genomics · 2007Article
- RNA editing and alternative splicing: the importance of co-transcriptional coordination.EMBO reports · 2006Article
- Role of the mammalian RNA polymerase II C-terminal domain (CTD) nonconsensus repeats in CTD stability and cell proliferation.Molecular and cellular biology · 2005Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The phosphorylation of the RNA polymerase II (Pol II) C-terminal domain (CTD) has been shown to affect the initiation, and transition to elongation of the Pol II complex. The differential phosphorylation of serines within this domain coincides with the recruitment of factors important for pre-mRNA processing and transcriptional elongation. A role for tyrosine and threonine phosphorylation has yet to be described. The discovery of kinases that express a preference for specific residues within this sequence suggests a mechanism for the controlled recruitment and displacement of CTD-interacting partners during the transcription cycle. The last CTD repeat (CTD52) contains unique interaction sites for the only known CTD tyrosine kinases, Abl1/c-Abl and Abl2/Arg, and the serine/threonine kinase casein kinase II (CKII). Here, we show that removal or severe disruption of the last CTD repeat, but not point mutation of its CKII sites, results in its proteolytic degradation to the Pol IIb form in vivo, but does not appear to affect the specific transcription of genes. These results suggest a possible mechanism of transcription control through the proteolytic removal of the Pol II CTD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.